A deep learning system for predicting time to progression of diabetic retinopathy.

Diabetic retinopathy (DR) is the leading cause of preventable blindness worldwide. The risk of DR progression is highly variable among different individuals, making it difficult to predict risk and personalize screening intervals. We developed and validated a deep learning system (DeepDR Plus) to predict time to DR progression within 5 years solely from fundus images.

Anatomical and Functional Outcomes in Delayed Onset versus Concurrent Retinal Detachment in Endophthalmitis.

Purpose: To determine the functional and anatomical outcomes of patients with endophthalmitis with concurrent or delayed onset retinal detachment (RD), and compare the preoperative, intraoperative and postoperative features.

Patients And Methods: This was a retrospective review of 121 eyes in 121 patients presenting with endophthalmitis and RD. Subjects were categorized into two groups: endophthalmitis with delayed onset RD (group 1, N=76) and endophthalmitis with concurrent RD (group 2, N=45).

Morphological and functional retinal changes in neovascular age-related macular degeneration treated with intravitreal bevacizumab.

Purpose: This study was conducted to determine the morphological and functional retinal changes in patients with neovascular age-related macular degeneration (nAMD) treated with intravitreal bevacizumab 1.25 mg.

Methods: This was a prospective, nonrandomized, interventional study.

Influence of Different Types of Retinal Cameras on the Performance of Deep Learning Algorithms in Diabetic Retinopathy Screening.

The aim of this study was to assess the performance of regional graders and artificial intelligence algorithms across retinal cameras with different specifications in classifying an image as gradable and ungradable. Study subjects were included from a community-based nationwide diabetic retinopathy screening program in Thailand. Various non-mydriatic fundus cameras were used for image acquisition, including Kowa Nonmyd, Kowa Nonmyd α-DⅢ, Kowa Nonmyd 7, Kowa Nonmyd WX, Kowa VX 10 α, Kowa VX 20 and Nidek AFC 210.

Distribution of macular pigments in macular telangiectasia type 2 and correlation with optical coherence tomography characteristics and visual acuity.

Background: To estimate macular pigment values in macular telangiectasia (MacTel) Type 2 in comparison with healthy subjects in the South Indian population across different spatial profiles and to quantify the regional differences of macular pigment optical density (MPOD) in MacTel Type 2.

Methods: In this prospective cross-sectional study, healthy controls and patients diagnosed with various stages of MacTel Type 2 underwent MPOD measurement using dual-wavelength autofluorescence technique with Spectralis HRA + OCT.

Results: Sixty eyes of 31 healthy subjects and 41 eyes of 22 MacTel type 2 patients were included.

Prevalence, risk factors and association with glycemic levels of presbyopia in South Indian population.

Purpose: To determine the prevalence of presbyopia and its association with elevated glycemic levels in subjects ≥40 years of age in the South Indian population of Chennai.

Methods: This was a retrospective study. Subjects were included from the Sankara Nethralaya Diabetic Retinopathy Epidemiology And Molecular genetics Study (SN-DREAMS 1).

Visual outcomes following cataract surgery with intraocular lens implantation in vitrectomized eyes among children.

Purpose: To assess the visual outcomes and associated factors in pediatric patients undergoing cataract surgery following pars plana vitrectomy (PPV).

Methods: A total of 52 eyes of 52 children who underwent cataract surgery and intraocular lens (IOL) implantation in previously vitrectomized eyes between January 2008 and December 2017 were included in this retrospective study. Descriptive and inferential statistical measurements (Chi-square test, Fisher's exact test, odds ratio, multiple logistic regression) were done.

Incidence and risk factors for retinal detachment following laser-assisted keratomileusis.

Purpose: The aim of this work was to study the incidence and potential risk factors for development of retinal detachment (RD) after laser-assisted in situ keratomileusis (LASIK) surgery over a long-term follow-up.

Methods: This was a retrospective interventional case series. A total of 694 eyes of 352 patients were included who had undergone LASIK surgery at a tertiary eye care institute between January 2005 and September 2015 who had a minimum follow-up of 5 years after the surgery were included.

Association Between Gut Microbial Abundance and Sight-Threatening Diabetic Retinopathy.

Purpose: To study the association between gut microbial abundance and sight-threatening diabetic retinopathy among patients with a history of type 2 diabetes mellitus.

Methods: An observational case-control study was performed using a sample population of diabetics referred to a tertiary eye institute. Sample subjects were identified as cases if they were diagnosed with sight-threatening diabetic retinopathy and controls if they were not but had at least a 10-year history of diabetes.

Accuracy of Intraocular Lens Power Calculation in Children With Vitrectomized Eyes Undergoing Cataract Surgery.

Purpose: To assess the predictability of desired postoperative refractive outcomes using the SRK-II formula for intraocular lens (IOL) power calculation in children undergoing cataract surgery in eyes with a previous pars plana vitrectomy (PPV).

Methods: In this retrospective study, 68 eyes of 66 children who underwent cataract surgery and IOL implantation in eyes that had previous vitrectomy between January 2008 and December 2017 were included. Data were collected on preoperative and postoperative characteristics.

Fluorophotometric Measurement of Corneal Autofluorescence in Diabetic and Normal Eyes.

Introduction: Corneal autofluorescence (AF) has been recommended as an indicator of diabetic retinopathy. This study was conducted to evaluate corneal autofluorescence in non-insulin dependent diabetes subjects (with and without diabetic retinopathy) and compare the changes with healthy subjects.

Materials And Methods: In this cross-sectional study, 145 eyes of diabetes mellitus subjects with and without diabetic retinopathy and 34 eyes of normal healthy subjects were included.

Evaluation of Macular Pigment Optical Density in Healthy Eyes Based on Dual-Wavelength Autofluorescence Imaging in South Indian Population.

Purpose: To estimate macular pigment optical density (MPOD) values across different age groups in the South Indian population across various spatial profiles using dual-wavelength autofluorescence.

Methods: Sixty eyes of 31 healthy subjects underwent MPOD measurement with Spectralis HRA+OCT. The average MPOD and macular pigment optical volume (MPOV) at 1°, 2°, and 6° radii, the mean MPOD in the classical Early Treatment Diabetic Retinopathy Study (ETDRS) grid, and the spatial profiles of two different age groups across 12 plots covering the radial sectors were recorded.