Calcium Alginate Bead-mediated Enhancement of the Selective Recovery of a Lead Novel Antifungal Bacillomycin Variant.

In the pursuit of new antifungal compounds, five coproduced lipopeptide variants (AF to AF) from wild-type Bacillus subtilis RLID 12.1 were identified in our previous study. Out of five, AF was identified as a novel lead molecule belonging to the bacillomycin family showing less cytotoxicity at its respective minimum inhibitory concentrations (MIC) evaluated against 81 strains of Candida and Cryptococcus species (including clinical isolates); besides this, AF purified in the present study exhibited encouraging MIC values against 10 clinical mycelial fungi.

Evaluation of Antifungal Efficacy of Three New Cyclic Lipopeptides of the Class Bacillomycin from Bacillus subtilis RLID 12.1.

New lipopeptide homologues (AF, AF, and AF) with antifungal activities against and spp. were purified from a cell-free supernatant of RLID 12.1.

A broad-spectrum antimicrobial activity of Bacillus subtilis RLID 12.1.

In the present study, an attempt was made to biochemically characterize the antimicrobial substance from the soil isolate designated as RLID 12.1 and explore its potential applications in biocontrol of drug-resistant pathogens. The antimicrobial potential of the wild-type isolate belonging to the genus Bacillus was determined by the cut-well agar assay.

Autosomal recessive juvenile onset cataract associated with mutation in BFSP1.

A genome wide scan in a consanguineous family of Indian origin with autosomal recessive developmental cataracts was performed by two-point linkage analysis with 382 microsatellite markers. It showed linkage to markers on chromosome 20q, between D20S852 and D20S912, with a maximum lod score of 5.4 obtained with D20S860.