Publications by authors named "Ramya Narendrula-Kotha"
Article Synopsis
- Nicotinic acetylcholine receptors (nAChRs), traditionally known for their role as ion channels in the nervous system, also appear to influence inflammation by promoting a desensitized state rather than channel activation.
- A study found that a silent agonist of α7 nAChRs, m-bromo PEP, effectively reduced inflammation and improved outcomes in an animal model of multiple sclerosis, impacting immune cell function and cytokine production.
- These findings suggest that α7 nAChR-selective silent agonists could serve as new anti-inflammatory treatments for various inflammatory disorders.
Metal Toxicity and Resistance in Plants and Microorganisms in Terrestrial Ecosystems.
Rev Environ Contam Toxicol
August 2019
Metals are major abiotic stressors of many organisms, but their toxicity in plants is not as studied as in microorganisms and animals. Likewise, research in plant responses to metal contamination is sketchy. Candidate genes associated with metal resistance in plants have been recently discovered and characterized.
View Article and Find Full Text PDFMetal and sulfur dioxide (SO) contaminations in Northern Ontario (Canada), especially in the Greater Sudbury Region (GSR) caused by mining activities have resulted in severe environmental degradations. A long term restoration program has led to significant landscape changes and healthy ecosystems. The objective of this study was to assess variation in enzymatic activities and soil respiration in metal contaminated and reclaimed ecosystems.
View Article and Find Full Text PDFAims: To assess the effects of dolomitic limestone applications on soil microbial communities' dynamics and bacterial and fungal biomass, relative abundance, and diversity in metal reclaimed regions.
Methods And Results: The study was conducted in reclaimed mining sites and metal uncontaminated areas. The limestone applications were performed over 35 years ago.