Targeted Degradation of CDK9 Potently Disrupts the MYC Transcriptional Network.

Unlabelled: Cyclin-dependent kinase 9 (CDK9) coordinates signaling events that regulate RNA polymerase II (Pol II) pause-release states. It is an important co-factor for transcription factors, such as MYC, that drive aberrant cell proliferation when their expression is deregulated. CDK9 modulation offers an approach for attenuating dysregulation in such transcriptional programs.

Role of ehealth literacy, learning styles, and patterns of web-based e-content access for seeking health information among dental university students in Vadodara, India.

Background: Individual's learning style, ehealth literacy, and preferred web-based e-content and channel to access information determines how one makes sense of health information on the Internet. Understanding these dynamics will help design suitable e-contents and choose appropriate channels for effective health communication. To assess the relationship between ehealth literacy, learning styles, and web-based e-content accessed for receiving health information among dental college students in Vadodara, India.

Impact of COVID-19 on quality checks of solid tumor molecular diagnostic testing-A surveillance by EQAS provider in India.

Background: Molecular tests in solid tumours for targeted therapies call for the need to ensure precision testing. To accomplish this participation in the External Quality Assessment Program (EQAS) is required. This evaluates the consistency of diagnostic testing procedures and offers guidance for improving quality.

ID3 promotes homologous recombination via non-transcriptional and transcriptional mechanisms and its loss confers sensitivity to PARP inhibition.

The inhibitor of DNA-binding 3 (ID3) is a transcriptional regulator that limits interaction of basic helix-loop-helix transcription factors with their target DNA sequences. We previously reported that ID3 loss is associated with mutational signatures linked to DNA repair defects. Here we demonstrate that ID3 exhibits a dual role to promote DNA double-strand break (DSB) repair, particularly homologous recombination (HR).

A qualitative research analysis of gender-based parities and disparities at work place experienced by female dentists of Vadodara, India.

Aim: To assess the gender-based parities and disparities at work place experienced by female dentists of Vadodara, India.

Materials And Methods: In-depth face-to-face qualitative semi-structured interviews in English were conducted among 12 female dentists of Vadodara. Female dentists working with one/more male colleague or auxiliary were selected through purposive sampling.

The effect of oil pulling with rice bran oil, sesame oil, and chlorhexidine mouth rinsing on halitosis among pregnant women: A comparative interventional study.

Context: Rice bran oil, owing to its potential antioxidant benefits, could be an effective and novel alternative to sesame oil for oil pulling. As it is safe and a growingly popular edible oil, it may be acceptable during pregnancy, especially in the Indian context where women may be hesitant to use chemical plaque control methods for preventing halitosis.

Aims: The present study was conducted to compare the effects of oil pulling with rice bran oil, oil pulling with sesame oil, and oil pulling with chlorhexidine mouth rinsing on reducing halitosis among pregnant women.

Comparisons of in vitro penetration and adaptation of moisture tolerant resin sealant and conventional resin sealant in different fissure types.

Objective: To compare the penetration and adaptation of a moisture tolerant resin-based sealant with a conventional resin-based sealant in different occlusal fissure types in vitro by scanning electron microscopic (SEM) technique.

Methods: Fifty sound, intact extracted premolars and third molars were included. They were randomly and equally allocated to receive either Seal-Rite (conventional resin-based sealant) or Embrace WetBond (moisture-tolerant resin-based sealant).

Determination of folate/folic acid level in milk by microbiological assay, immuno assay and high performance liquid chromatography.

A concurrent determination of folate versus folic acid in milk by microbiological assay (MA) with Lactobacillus rhamnosus as the assay organism, Enzyme Linked Immuno Sorbent Assay (ELISA) by competitive binding rapid ELISA kit (RIDASCREEN®) and high-pressure-liquid chromatography (HPLC) was done for detection of the folate form and its level. MA gave total folate content as Lb. rhamnosus showed similar response to most folate isomers formed by the tri-enzyme treatment in comparison with the other two methods which specifically estimated the folic acid.

Prevalence of periodontal disease among inpatients in a psychiatric hospital in India.

This paper assessed the periodontal status of inpatients at Government Mental Hospital, Vadodara, India, and studied the possible relationship between periodontal status and age, length of hospitalization, type of mental illness, and medication and tobacco use. Information about psychiatric diagnosis, length of hospitalization, and prescribed medication was obtained from hospital records. We interviewed 165 inpatients and recorded their chief dental complaints (if any) and relevant histories.

Dietary effect of folate-rich fermented milk produced by Streptococcus thermophilus strains on hemoglobin level.

Objective: Folate, a water-soluble vitamin, functions as a carbon carrier in the formation of heme, the iron-containing non-protein portion of hemoglobin. Therefore, its deficiency leads to anemia. The objective of this study was to determine the dietary effects of folate-rich fermented milk produced by high-folate-producing Streptococcus thermophilus strains (RD 102 and RD 104) on hemoglobin level using a murine model.

Folate: a functional food constituent.

Folate, a water-soluble vitamin, includes naturally occurring food folate and synthetic folic acid in supplements and fortified foods. Mammalian cells cannot synthesize folate and its deficiency has been implicated in a wide variety of disorders. A number of reviews have dwelt up on the health benefits associated with increased folate intakes and many countries possess mandatory folate enrichment programs.

Response surface optimization of the cultivation conditions and medium components for the production of folate by Streptococcus thermophilus.

Optimization of the cultivation conditions and medium components for folate production by the highest folate producing Streptococcus thermophilus strain RD102 was carried out using a 23 central composite design and surface modelling method of response surface methodology. As folate production was observed to be growth-associated, hence the desired responses selected for the optimization were both folate production and growth. The selected factors based on preliminary investigations were incubation period, concentrations of p-amino benzoic acid (PABA) the growth precursor, and lactose as carbon source.