Mitigating cyclophosphamide-associated gonadotoxicity in male rats: exploring the therapeutic potential of hesperidin.

Hesperidin, a bioactive flavanone glycoside prevalent in citrus fruits, with remarkable therapeutic properties stands out as a formidable defender against the debilitating reproductive toxicity associated with Cyclophosphamide (CYP) chemotherapy. This study explores the protective potential of hesperidin (HSP@100 mg/kg b.wt PO daily) against CYP-induced (@ 40 mg/kg b.

Fabrication of sandwich structures of Ag/analyte/MoOsea urchins for SERS detection of methylene blue dye molecules.

A substrate for surface-enhanced Raman spectroscopy (SERS) in a sandwich configuration, noble metal/analyte/defect-rich metal oxide, is demonstrated for the detection of methylene blue(MB). The sandwich structure (Ag/MB/SUMoO) is fabricated by physical vapour deposition of Ag nanoparticles over the MB analytes that are adsorbed on sea urchin MoO(SUMoO). SUMoOare grown on a glass substrate by chemical bath deposition.

Efficacy of Residential, Group-Based, Intensive Holistic Lifestyle Intervention Among Type-2 Diabetes Patients - A Single Group Pre- And Post-intervention Study.

Background The present study assessed the efficacy of the residential, group-based, intensive holistic lifestyle intervention on glycaemic control. Materials and methods A one-group pre and post-intervention study was conducted among 145 people with diabetes for a period of one year from February 2019 to January 2020. The study population underwent "Brahma Kumaris Raja Yoga lifestyle" intervention.

Designing siRNA/chitosan-methacrylate complex nanolipogel for prolonged gene silencing effects.

Despite immense revolutionary therapeutics potential, sustaining release of active small interfering RNA (siRNA) remains an arduous challenge. The development of nanoparticles with siRNA sustained release capabilities provides an avenue to enhance the therapeutic efficacy of gene-based therapy. Herein, we present a new system based on the encapsulation of siRNA/chitosan-methacrylate (CMA) complexes into liposomes to form UV crosslinkable Nanolipogels (NLGs) with sustained siRNA-release properties in vitro.

Clinical profile and risk factors for mortality among COVID-19 inpatients at a tertiary care centre in Bengaluru, India.

COVID-19 is an emerging viral disease affecting more than 200 countries worldwide and it present with varied clinical profile throughout the world. Without effective drugs to cure COVID-19, early identification and control of risk factors are important measures to combat COVID-19.  This study was conducted to determine the clinical profile and risk factors associated with mortality among COVID-19 patients in a tertiary care hospital in South India.

Smart Simon Bot with Public Sentiment Analysis for Novel Covid-19 Tweets Stratification.

In present modern era, the outbreak of COVID-19 pandemic has created informational crisis. The public sentiments collected from different reflexions (hashtags, comments, tweets, posts of twitter) are measured accordingly, ensuring different policy decisions and messaging are incorporated. The implementation demonstrates intuition in to the advancement of fear sentiment eventually as COVID-19 approaches maximum levels in the world, by making use of detailed textual analysis with the help of required text data visualization.

Gold Nanorods as an Efficient Substrate for the Detection and Degradation of Pesticides.

The rapid, ultralow detection, degradation, and complete removal of pesticides demand the design of potential substrates. Herein, we discussed gold nanorods (Au NRs) as the potential substrate for the naked eye detection and degradation of two common and broad-spectrum pesticides, chlorpyrifos (CPF) and malathion (MLT), up to 0.15 ppt concentration within 2 min.

A Comparative Study of the Efficacy of Fat Plug Myringoplasty and Conventional Myringoplasty in Chronic Suppurative Otitis Media with Small Central Perforation.

Chronic Otitis Media (COM) is a major cause of acquired hearing impairment especially in developing countries. Persistent perforations occur either due to improper treatment of recurrent otitis media or infected traumatic perforation. Myringoplasty, repair of the Tympanic membrane using autologous temporalis fascia, is the standard procedure for COM.

Utility of urine reagent strips in cerebrospinal fluid analysis: An aid to bedside diagnosis of meningitis.

Context: The provision of initial treatment to a patient with suspected meningitis depends greatly on early recognition and rapid diagnostic evaluation of cerebrospinal fluid (CSF) leukocytes, proteins, and glucose. The diagnosis is time critical and timely intervention has an implication on the prognosis and outcome. Reasonably, sound laboratorial setups are not available in our country in the primary health-care level and, even in the settings where they are available, long waiting periods precede the availability of results.

Design and development of benzoxazole derivatives with toll-like receptor 9 antagonism.

Toll-like receptor 9 (TLR9) is a major therapeutic target for numerous inflammatory disorders. Development of small molecule inhibitors for TLR9 remains largely empirical due to lack of structural understanding of potential TLR9 antagonism by small molecules and due to the unusual topology of the ligand binding surface of the receptor. To develop a structural model for rational design of small molecule TLR9 antagonists, an enhanced homology model of human TLR9 (hTLR9) was constructed.

Integrative Taxonomic Approach for Describing a New Cryptic Species of Bush Frog (Raorchestes: Anura: Rhacophoridae) from the Western Ghats, India.

A new cryptic species of bush frog Raorchestes honnametti sp. nov. is described from the south-eastern part of the Western Ghats, India.

Amyloidosis of the tongue-report of a rare case.

Amyloid involvement of the tongue is almost always secondary to systemic amyloidosis. Isolated amyloidosis of the tongue is relatively rare and it accounts for less than 9% of all types of amyloidosis. We are presenting a case of a 54-year-old male patient who complained of an enlarged tongue and bilateral multiple swellings on the lateral borders of the tongue, which had been there since one year.

Linear accelerator: a reproducible, efficacious and cost effective alternative for blood irradiation.

Background: The dedicated devices for blood irradiation are available only at a few centers in developing countries thus the irradiation remains a service with limited availability due to prohibitive cost.

Objective: To implement a blood irradiation program at our center using linear accelerator.

Materials And Methods: The study is performed detailing the specific operational and quality assurance measures employed in providing a blood component-irradiation service at tertiary care hospital.