Publications by authors named "Ramy Mohamed Mahmoud"
BMC Med Genomics
August 2024
Article Synopsis
- Hepatocellular carcinoma (HCC) is the most common liver cancer, often caused by chronic hepatitis and cirrhosis, with this study aiming to examine the genomic characteristics of HCC in Egyptian patients through whole exome sequencing.
- Whole exome sequencing was performed on 13 HCC patients who underwent surgery, revealing specific mutational signatures and a set of highly mutated genes associated with HCC, including notable mutations in APOB and RP1L1 across multiple studies.
- The findings confirmed previously established patterns in HCC genetics, identifying critical signaling pathways and potential clinical targets, highlighting the importance of these mutations for future research and therapy development.
