Biochemical processes mediating neurotoxicity induced by synthetic food dyes: A review of current evidence.

The extensive use of synthetic food dyes in the food industry, primarily due to their durability and cost-effectiveness compared to natural colorants, has raised significant health concerns. Of particular concern are the potential neurotoxic effects of six commonly used synthetic food dyes: Tartrazine (E102/FD&C Yellow No. 5), Erythrosine (E127/FD&C Red No.

Investigation of rank order centroid method for optimal generation control.

Multi-criteria decision-making (MCDM) presents a significant challenge in decision-making processes, aiming to ascertain optimal choice by considering multiple criteria. This paper proposes rank order centroid (ROC) method, MCDM technique, to determine weights for sub-objective functions, specifically, addressing issue of automatic generation control (AGC) within two area interconnected power system (TAIPS). The sub-objective functions include integral time absolute errors (ITAE) for frequency deviations and control errors in both areas, along with ITAE of fluctuation in tie-line power.

Topical Esmolol Hydrochloride as a Novel Treatment Modality for Diabetic Foot Ulcers: A Phase 3 Randomized Clinical Trial.

Importance: Preclinical and phase 1/2 studies with esmolol hydrochloride suggest its potential role in treatment of diabetic foot ulcers (DFUs).

Objective: To study the efficacy of topical esmolol for healing of uninfected DFUs.

Design, Setting, And Participants: A randomized, double-blind, multicenter, phase 3 clinical trial was conducted from December 26, 2018, to August 19, 2020, at 27 referral centers across India.

Nanotechnology, Green Synthesis and Biological Activity Application of Zinc Oxide Nanoparticles Incorporated Argemone Mxicana Leaf Extract.

Nanomaterial is a rapidly growing area that is used to create a variety of new materials and nanotechnology applications from medical, pharmaceuticals, chemical, mechanical, electronics and several environmental industries including physical, chemical and biological nanoparticles are very important in our daily life. Nanoparticles with leaf extract from the healthy plant are important in the area of research using biosynthesis methods. Because of it's used as an environmentally ecofriendly, other than traditional physical and chemical strategies.

Hydrogeochemical characteristics of groundwater uses for agricultural and drinking and groundwater quality of pollution index in the western part of Telangana, South India.

A total of fifty groundwater samples were collected in the western part of Nizamabad district, Telangana State, India. The results obtained were compared with the IS 10500 standard, which shows more than 80% of the samples are unfit for drinking purposes. The results were also analyzed to know the irrigation suitability, where about 80% of the samples are fit for agricultural use.

Public debt sustainability in sub-national level: a case of Karnataka.

This paper attempts to empirically measure the public debt sustainability of Karnataka State in India for the period starting from 1991 to 2018. Three well-established methods are adopted to measure public debt sustainability, namely, indicator approach, time series approach and sensitivity analysis. The indicator approach shows that Karnataka's public debt satisfies Domer (1944) debt sustainability condition.

Glycemic parameters in patients with new-onset diabetes during COVID-19 pandemic are more severe than in patients with new-onset diabetes before the pandemic: NOD COVID India Study.

Background And Aims: It is not known if new onset diabetes during Coronavirus-19 disease (COVID-19; NOD COVID) is phenotypically or biochemically different than new onset diabetes before COVID-19 (NOD).

Methods: All adults diagnosed with new onset diabetes from during the time of COVID-19 were compared with new onset diabetes prior to COVID-19 from two tertiary care hospitals in Chennai and Delhi. RTPCR test for SARS-CoV-2 virus was done as appropriate, and COVID-19 antibody test was done in all other NOD COVID patients.

Ultimate Spin Currents in Commercial Chemical Vapor Deposited Graphene.

Establishing ultimate spin current efficiency in graphene over industry-standard substrates can facilitate research and development exploration of spin current functions and spin sensing. At the same time, it can resolve core issues in spin relaxation physics while addressing the skepticism of graphene's practicality for planar spintronic applications. In this work, we reveal an exceptionally long spin communication capability of 45 μm and highest to date spin diffusion length of 13.

A ProspectIve, OpeN-Label, Randomized Study Comparing EffIcacy and Safety of Teneligliptin VErsus Sitagliptin in Indian Patients with Inadequately Controlled Type 2 Diabetes Mellitus: INSITES Study.

Background: Teneligliptin is widely prescribed dipeptidyl peptidase-4 inhibitor (DPP-4i) in India because of its economical pricing. However, there is no headto-head trial comparing teneligliptin with any other DPP-4i in Indian setting. We evaluated the efficacy and safety of teneligliptin versus sitagliptin as add-on to metformin and/or sulfonylureas in patients with type 2 diabetes mellitus (T2DM).

Optimization of the configuration of porous bone scaffolds made of Polyamide/Hydroxyapatite composites using Selective Laser Sintering for tissue engineering applications.

Numerous biomaterials are used to fabricate bone scaffolds to repair the bones subjected to trauma. The scaffolds are fabricated with interconnected pores with 40-70% porosity to facilitate the entry of the cells that ensures rapid bone formation. In addition, the interconnected pores also serve as a channel for the exchange of nutrients and waste materials.

Apixaban and Rosuvas--tatin Pharmacokinetics in Nonalcoholic Fatty Liver Disease.

There is little known about the impact of nonalcoholic fatty liver disease (NAFLD) on drug metabolism and transport. We examined the pharmacokinetics of oral apixaban (2.5 mg) and rosuvastatin (5 mg) when administered simultaneously in subjects with magnetic resonance imaging-confirmed NAFLD ( = 22) and healthy control subjects ( = 12).

Synthetic biology approaches: Towards sustainable exploitation of marine bioactive molecules.

The discovery of genes responsible for the production of bioactive metabolites via metabolic pathways combined with the advances in synthetic biology tools, has allowed the establishment of numerous microbial cell factories, for instance the yeast cell factories, for the manufacture of highly useful metabolites from renewable biomass. Genome mining and metagenomics are two platforms provide base-line data for reconstruction of genomes and metabolomes which is based in the development of synthetic/semi-synthetic genomes for marine natural products discovery. Engineered biofilms are being innovated on synthetic biology platform using genetic circuits and cell signalling systems as represillators controlling biofilm formation.

A Multicenter Real-Life Study on the Effect of Flash Glucose Monitoring on Glycemic Control in Patients with Type 1 and Type 2 Diabetes.

Aim: To assess the efficacy of ambulatory glucose profiling (AGP) generated by FreeStyle LibrePro flash glucose monitoring (FCGM) on glycemic control in patients with uncontrolled type 1 diabetes (T1D) and type 2 diabetes (T2D).

Methods: Clinical and biochemical data were obtained from 5072 patients with diabetes who had an A1c ≥7% (2536 who had been initiated on FCGM-based AGP between March 2015 and October 2016 [cases] and 2536 age-, gender-, A1c-, site- and time-matched controls who were not initiated on AGP) across seven diabetes clinics in India. Anthropometric and clinical measurements were obtained through standardized techniques.

Role of RKKY torque on domain wall motion in synthetic antiferromagnetic nanowires with opposite spin Hall angles.

We experimentally show the effect of enhanced spin-orbit and RKKY induced torques on the current-induced motion of a pair of domain walls (DWs), which are coupled antiferromagnetically in synthetic antiferromagnetic (SAF) nanowires. The torque from the spin Hall effect (SHE) rotates the Néel DWs pair into the transverse direction, which is due to the fact that heavy metals of opposite spin Hall angles are deposited at the top and the bottom ferromagnetic interfaces. The rotation of both DWs in non-collinear fashion largely perturbs the antiferromagnetic coupling, which in turn stimulates an enhanced interlayer RKKY exchange torque that improved the DW velocity.

Identification of New Inhibitors for Human SIRT1: An in-silico Approach.

Background: Human SIRT1 is a class III histone deacetylase (HDAC) family protein. As the overexpression of hSIRT1 leads to cancer, inhibiting its HDAC function may be a better strategy for the treatment of cancer. Till now, only a few reported inhibitor compounds have reached the stage of animal studies; hence, identifying high efficacy inhibitors of hSIRT1 is essential.

Transverse domain wall profile for spin logic applications.

Domain wall (DW) based logic and memory devices require precise control and manipulation of DW in nanowire conduits. The topological defects of Transverse DWs (TDW) are of paramount importance as regards to the deterministic pinning and movement of DW within complex networks of conduits. In-situ control of the DW topological defects in nanowire conduits may pave the way for novel DW logic applications.

Quantitative evaluation of 3D dosimetry for stereotactic volumetric-modulated arc delivery using COMPASS.

The purpose of this study was to evaluate quantitatively the patient-specific 3D dosimetry tool COMPASS with 2D array MatriXX detector for stereotactic volumetric-modulated arc delivery. Twenty-five patients CT images and RT structures from different sites (brain, head & neck, thorax, abdomen, and spine) were taken from CyberKnife Multiplan planning system for this study. All these patients underwent radical stereotactic treatment in CyberKnife.

All-electrical deterministic single domain wall generation for on-chip applications.

Controlling domain wall (DW) generation and dynamics behaviour in ferromagnetic nanowire is critical to the engineering of domain wall-based non-volatile logic and magnetic memory devices. Previous research showed that DW generation suffered from a random or stochastic nature and that makes the realization of DW based device a challenging task. Conventionally, stabilizing a Néel DW requires a long pulsed current and the assistance of an external magnetic field.

A compendium of molecules involved in vector-pathogen interactions pertaining to malaria.

Malaria is a vector-borne disease causing extensive morbidity, debility and mortality. Development of resistance to drugs among parasites and to conventional insecticides among vector-mosquitoes necessitates innovative measures to combat this disease. Identification of molecules involved in the maintenance of complex developmental cycles of the parasites within the vector and the host can provide attractive targets to intervene in the disease transmission.

Prevalence of neuropathy in type 2 diabetic patients attending a diabetes centre in South India.

Objective: The aim of this study was to determine the prevalence and risk factors for neuropathy among South Indian type 2 diabetic patients attending a diabetes centre.

Methods: One thousand consecutive type 2 diabetic patients attending a diabetes centre in South India were recruited for the study. Biothesiometry studies were performed by a single observer using a biothesiometer.

Oversized grafts in children.

Objective: To evaluate the efficacy of oversized corneal grafts in the pediatric age group.

Design: Prospective, nonrandomized clinical trial.

Participants And Intervention: Forty pediatric patients with unilateral or bilateral corneal opacification of congenital or acquired origin underwent corneal grafting surgery over a period of 2 years using donor corneal buttons oversized by 1 mm.

MANOVIKARA (Mental disorders) IN AYURVEDA.

An attempt is made to project at one place the available Ayurvedic material on manas and treatment of manovikara in an orderly manner which would be both easy to understand and rewarding in the field of treatment, by describing the definition of manas, its functions, qualities, concept of psychosomatics, classification of mental disorders, treatment of mental illness prevention of mental illnesses, method of examination of mental illness and other important aspects.

A pilot study of role of brahmyadiyoga in chronic unmada(schizophrenia).

Brahmyadiyoga a compound drug was used on fourteen Chronic Unmada patients suffering from 2 years to 8 years between the ago range of 18 to 40 years of either sex. The dose of the drug was 8 gms. to 16 gms.