Spectroscopic, SOD, anticancer, antimicrobial, molecular docking and DNA binding properties of bioactive VO(IV), Cu(II), Zn(II), Co(II), Mn(II) and Ni(II) complexes obtained from 3-(2-hydroxy-3-methoxybenzylidene)pentane-2,4-dione.

Novel macrocyclic Schiff base complexes [[ML]X; where M = Cu(II), Co(II), Ni(II), Zn(II), Mn(II) and VO(IV) L = macrocyclic ligand; X = Cl and SO] have been synthesized and characterized by microanalytical, H, C NMR, IR, Mass, UV-Vis, EPR spectral studies, as well as conductivity data. All the complexes exhibit square-planar geometry except vanadium complex. Magnetic susceptibility measurements and high conductance data reveal the monomeric and electrolytic nature of the complexes.

Synthesis and photophysical properties of pyridyl conjugated triazole appended naphthalenediimide derivatives.

A series of three substituted triazole appended NDI-derivatives, 2,7-bis(3,5-di(pyridin-X-yl)-4H-1,2,4-triazol-4-yl)benzo[lmn][3,8]phenanthroline-1,3,6,8(2H,7H)-tetraone (where X = 2, NDI-PyTz-1; 3, NDI-PyTz-2; and 4, NDI-PyTz-3), were designed, synthesized and well characterized using various analytical and spectroscopic techniques. All the three NDI-PyTz derivatives exhibit decent electronic properties as suggested by DFT, cyclic voltammetry and fluorescence studies. In particular, NDI-PyTz-1 demonstrated the generation of a stable anion radical [NDI-PyTz-1]˙-.

EGFR, HER2 target based molecular docking analysis, in vitro screening of 2, 4, 5-trisubstituted imidazole derivatives as potential anti-oxidant and cytotoxic agents.

In our endeavor towards the development of potent molecules for cancer diseases, we have designed and synthesized a series of 2,4,5-trisubstituted imidazole derivatives (B1-B24) and characterized by using various spectroscopic techniques. All these compounds are further evaluated for their in vitro anti-cancer, anti-oxidant activities and molecular docking studies against EGFR, HER2 protein receptors. The in vitro anti-cancer activity analysis reveals that compounds B11 and B16 were found to be effective scaffolds against the tested human cancer cell lines IMR-32, A549 and HeLa.

Design, synthesis and biological evaluation of 8-substituted-6-hydrazonoindolo[2,1-b]quinazolin-12(6H)-one scaffolds as potential cytotoxic agents: IDO-1 targeting molecular docking studies.

Herein, we have reported the synthesis of 18 novel 8-substituted tryptanthrin analogues based on our earlier work. All these tryptanthrin analogues were well characterized by H &C NMR, FT-IR, Mass Spectrometry and Elemental Analysis. All these 8-substituted analogues were screened for their anti-oxidant activity by DPPH radical scavenging assay.

A Functional Zn(II) Metallacycle Formed from an N-Heterocyclic Carbene Precursor: A Molecular Sensor for Selective Recognition of Fe and IO Ions.

We have reported the synthesis and structural characterization of a unique Zn(II) metallacycle (1) and its utilization as a fluorescent probe for the shape-specific selective recognition (turn-off) of Fe and IO ions. The relevant Stern-Volmer graphs indicate that the recognitions of Fe and IO ions are examples of diphasic and monophasic quenchings, respectively. The title metallacycle has been prepared by the reaction of a novel N-heterocyclic carbene precursor, 1,3-bis(2,6-diisopropyl-4-(pyridin-4-yl)phenyl)-1H-imidazol-3-ium chloride/bromide (L), and zinc(II) chloride salt.

Novel substituted hydrazono indolo[2,1-b]quinazoline-6,12-dione analogues as cytostatic agents: Synthesis, crystal structure, biological evaluation and molecular docking studies.

A series of novel substituted hydrazono indolo[2,1-b]quinazoline-6,12-dione analogues have been synthesized and screened for their in vitro cytotoxic and antimicrobial activities. Among all the target compounds, 3c exhibited the most potent inhibitory activity against three cancer cell lines MCF-7, A549, HeLa with IC values 07.14±1.