Publications by authors named "Ramswaroop Mundada"
Article Synopsis
- HIF-1α and STAT3 are important transcription factors activated by low oxygen levels and play key roles in cancer processes like cell survival and growth.
- Overexpression of these factors is common in many human cancers, making them attractive targets for new cancer drugs.
- The study presents a new compound, P3971, which effectively inhibits both HIF-1α and STAT3, showing strong anti-cancer activity in lab tests and in animal models for colon and lung cancers.
Article Synopsis
- The study presents the development of new furoquinoline-based molecules (compounds 16-36) and their effectiveness in inhibiting the PI3K/Akt signaling pathway and mTOR, demonstrated through both cell-based and cell-free assays.
- Compound 23 stands out for not only inhibiting the PI3K-mTOR pathway but also for significantly reducing the levels of HIF-1alpha protein in hypoxic conditions, particularly in U251-HRE cells.
- The effectiveness of compound 23 was validated through Western blot analysis on human non-small cell lung carcinoma H-460 cells and glioblastoma U251 cells.