Effects of short-term prednisolone treatment on indices of lipolysis and lipase signaling in abdominal adipose tissue in healthy humans.

Background: Glucocorticoid (GC) excess increases lipolysis, circulating free fatty acid concentrations and lipid oxidation rates in humans. In vitro and animal studies have shown that GCs increase adipocyte ATGL and HSL mRNA contents and HSL phosphorylations, but the effects of GC on in vivo lipase signaling in humans are uncertain. Our study was designed to test how GC administration affects ATGL and HSL related signals in human adipose tissue.

Effects of Prednisolone on Serum and Tissue Fluid IGF-I Receptor Activation and Post-Receptor Signaling in Humans.

Context: Short-term glucocorticoid exposure increases serum insulinlike growth factor I (IGF-I) concentrations but antagonizes IGF-I tissue signaling. The underlying mechanisms remain unknown.

Objective: To identify at which levels glucocorticoid inhibits IGF-I signaling.

The timing of administration of exogenous glucocorticoid affects 24hour growth hormone secretion in children.

Unlabelled: Exogenous glucocorticoids may suppress linear growth by affecting the diurnal secretory rhythm of GH.

Objective: To assess whether the timing of exogenous glucocorticoid administration affects GH secretion in children.

Design: Four girls and four boys aged 10.