Polymorphism in miRNA target sites of and ring complex influences expression of CEP genes and favors tumorigenesis in glioma.

The present study was designed to screen the genetic polymorphisms and expression profiling of and genes in brain tumor patients. The amplification refractory mutation system PCR technique (ARMS-PCR) was used for mutation analysis using 300 blood samples of brain tumor patients and 300 overtly healthy controls. For expression analysis, 150 brain tumor tissue samples along with adjacent uninvolved/normal tissues (controls) were collected.