Publications by authors named "Ramsey Mohl"
Background: Accurate quantification of malignant cells in the peripheral blood of patients with cutaneous T-cell lymphoma is important for early detection, prognosis, and monitoring disease burden.
Objective: We sought to determine the spectrum of current clinical practices; critically evaluate elements of current International Society for Cutaneous Lymphomas (ISCL) B1 and B2 staging criteria; and assess the potential role of T-cell receptor-Vβ analysis by flow cytometry.
Methods: We assessed current clinical practices by survey, and performed a retrospective analysis of 161 patients evaluated at Yale (2011-2014) to compare the sensitivity, specificity, positive predictive value, and negative predictive value of parameters for ISCL B2 staging.
Article Synopsis
- The study compares the traditional immunofluorescence antibody testing (IFA) method with two commercial enzyme immunoassay (EIA) kits for detecting malaria in patients.
- The Cellabs EIA showed the highest sensitivity (95.5%) and overall agreement (93.2%), while the Newmarket EIA had the highest specificity (96.1%) but lower sensitivity (68.2%).
- The findings suggest that the Cellabs EIA is a better option for diagnosing malaria, especially in cases where the blood smear test might miss infections, while the Newmarket EIA may be better for confirming negative results.