Publications by authors named "Ramona Pauli"
Delayed HIV diagnosis at advanced stages of disease remains common (33%-64%). This analysis of the multi-center FindHIV study including newly diagnosed HIV-infected adults in Germany, focused on the potential role of socio-demographic and psychological factors on late diagnosis (formerly "late presentation", AIDS diagnosis or CD4 cells <350/µL). These data were collected from patient profiles, physician-patient interviews and questionnaires.
View Article and Find Full Text PDFBackground: Since May 2022, increasing numbers of monkeypox virus (MPXV) infections have been reported from across Europe and North America. Studies, mainly from Africa, have suggested a higher risk for severe MPXV cases in people living with HIV.
Methods: This was a retrospective study of all confirmed MPXV infections observed in the participating centres since 19 May 2022.
Article Synopsis
- NK cells are crucial for fighting viral infections and use a variety of receptors, with HLA-C being the main ligand for Killer-cell immunoglobulin-like receptors (KIRs), influencing NK cell activity.
- The study shows that HIV-1 can evade the immune response by adapting to host genetics, particularly through the Vpu protein that downregulates HLA-C, which helps the virus escape detection by NK cells.
- Researchers found that HIV-1 infection leads to changes in the NK cell receptor profile, including an increase in specific NK cell populations and a genotype-dependent expansion of KIR2DL1, indicating a complex relationship between the immune response and HIV-1 evolution.
Functional Hypogonadism and Testosterone Deficiency in Aging Males With and Without HIV-infection.
Exp Clin Endocrinol Diabetes
November 2021
Introduction: HIV infection has become a chronic, well-treatable disease and the focus of caretakers has shifted to diagnosis and treatment of comorbidities. Hypogonadism in elderly men with HIV might be of particular relevance, however, little is known about its epidemiology in contrast to non-infected peers and men with other chronic medical conditions, such as type 2 diabetes. This study aimed at comparing the prevalence of testosterone deficiency and functional hypogonadism in men 50 years in these three groups.
View Article and Find Full Text PDFIn untreated HIV infection, the efficacy of T cell responses decreases over the disease course, resulting in disease progression. The reasons for this development are not completely understood. However, immunosuppressive cells are supposedly crucially involved.
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