Therapeutic Success of Tiotropium/Olodaterol, Measured Using the Clinical COPD Questionnaire (CCQ), in Routine Clinical Practice: A Multinational Non-Interventional Study.

Background: The Clinical COPD Questionnaire (CCQ) is a simple patient-reported tool to measure clinical control of chronic obstructive pulmonary disease (COPD).

Objective: This open-label, single-arm, non-interventional study (NCT03663569) investigated changes in CCQ score during treatment with tiotropium/olodaterol in clinical practice.

Methods: Data were included from consenting COPD patients, enrolled in Bulgaria, Czech Republic, Hungary, Israel, Lithuania, Poland, Romania, Russia, Slovenia, Switzerland and Ukraine, who were receiving a new prescription for tiotropium/olodaterol according to the treating physician in a real-world environment.

Smoking during pregnancy--a challenge to practitioners.

Smoking during pregnancy is a common finding among women whose parents have been smokers, among those whose husbands are smokers, among women who smoked more than 10 cigarettes per day before they became pregnant, and women who started to smoke at an early age. Smoking while pregnant is dangerous to both mother and child. Smoking exposure risks such as infertility (both primary and secondary), bleeding during pregnancy, abruptio placentae, placenta praevia, premature rupture of membranes, premature birth, low birth weight newborns, sudden infant death syndrome are taken into consideration.