Publications by authors named "Ramona Gowry Sivakumar"
Int J Mol Sci
November 2022
Article Synopsis
- Thyroid hormones and their receptors play a significant role in reducing liver triglycerides, suggesting that thyroid hormone analogs may help treat liver fat accumulation.
- MGL-3196, a new thyroid hormone analog, shows promise for targeting the liver without negative side effects associated with other receptor types, specifically TRα.
- The study found that MGL-3196 is effectively taken up by liver cells through the transporter OATP1B1 and selectively activates the TRβ receptor more than TRα, making it a strong candidate for therapeutic applications in liver conditions.
