Publications by authors named "Ramona E A van Heerebeek"
Article Synopsis
- A recent study identified SLC17A4 as a new transporter for the thyroid hormones T3 and T4, showing its ability to significantly increase their cellular uptake.
- The research involved various experimental approaches including assessing the effects of ion dependence, pH levels, and specific inhibitors on the transport function of SLC17A4.
- Findings revealed that this transporter functions independently of sodium and chloride, and is influenced by N-linked glycosylation, with specific Asn residues playing a crucial role in its activity.
Background: While thyroxine (T4), 3,3',5-triiodothyronine (T3), and 3,3',5'-triiodothyronine (rT3) have routine methods available for evaluating patients with suspected thyroid disease, appropriate methods for the measurement of other thyroid hormone metabolites (THMs) are lacking. The effects of other iodothyronines or iodothyroacetic acids are therefore less explored. To better understand the (patho)physiological role of THMs, a robust method to measure iodothyronines and iodothyroacetic acids in serum in a single analysis is needed, including associated reference intervals.
View Article and Find Full Text PDFMutations in the thyroid hormone (TH) transporter monocarboxylate transporter 8 (MCT8) cause MCT8 deficiency, characterized by severe intellectual and motor disability and abnormal serum thyroid function tests. Various knock-out mouse models as well as knock-out and knockdown zebrafish models are used as a disease model for MCT8 deficiency. Although important for model eligibility, little is known about the functional characteristics of the MCT8 orthologues in these species.
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