Publications by authors named "Ramona B Rudnick"
Article Synopsis
- Genetic variants in complement factor H (CFH) have been linked to age-related macular degeneration (AMD) by affecting CFH's ability to bind to modified self-ligands like malondialdehyde (MDA), disrupting complement regulation.
- A genome-wide study found specific genetic variants, such as rs1061170 and certain deletions, that influence CFH and its splice variant FHL-1’s binding capabilities to MDA in healthy individuals.
- FHR1 and FHR3 were identified as competitive binders that can inhibit CFH's function on MDA-modified surfaces, leading to increased complement activation and suggesting that specific genetic variations offer protection against AMD by improving tissue homeostasis.
Factor H related-protein 5 (CFHR5) is a surface-acting complement activator and variations in the CFHR5 gene are linked to CFHR glomerulonephritis. In this study, we show that FHR5 binds to laminin-521, the major constituent of the glomerular basement membrane, and to mesangial laminin-211. Furthermore, we identify malondialdehyde-acetaldehyde (MAA) epitopes, which are exposed on the surface of human necrotic cells (), as new FHR5 ligands.
View Article and Find Full Text PDF