The nose as a target organ in the diagnosis of severe aspirin-exacerbated respiratory disease.

Background: The nasal provocation test (NPT) with lysine aspirin is a useful tool in the diagnosis of aspirin-exacerbated respiratory disease (AERD), previously reffered to as Samter's disease. The aim of the present study focuses on methodological interventions to show the usefulness of the NPT with lysine aspirin in differentiating AERD patients from aspirin-tolerant asthma (ATA) patients to improve the diagnostic efficacy and minimize the risk for adverse reactions compared with the gold standard.

Methods: Thirty AERD patients comprised the active study group while the control group consisted of 25 ATA patients.