Publications by authors named "Ramon Pujol"
Article Synopsis
- - A study evaluated the effectiveness and safety of dupilumab for treating bullous pemphigoid in elderly patients, with a focus on those who typically have other health issues that make standard treatments unsuitable.
- - The results showed that 53.4% of patients achieved complete remission within 4 weeks and 95.7% by week 52, with a significant reduction in itchiness and a dramatic decrease in the need for corticosteroids.
- - The treatment was found to be safe, with most adverse events being mild, and factors like shorter disease duration and exclusive skin involvement were linked to better treatment responses.
Article Synopsis
- The Basophil Activation Test (BAT) is identified as a key biomarker for predicting autoimmune chronic spontaneous urticaria (aiCSU), but its real-world application and relation to omalizumab therapy are still under-researched.
- A study conducted between 2010 and 2024 analyzed the clinical and laboratory characteristics of patients with chronic spontaneous urticaria (CSU) based on their BAT results, collecting data on various biomarkers and treatment responses.
- Results showed that BAT positive patients exhibited specific traits such as low IgE levels and higher positivity for markers like anti-thyroid peroxidase; notably, these patients experienced shorter effectiveness of omalizumab treatment, highlighting the importance of BAT in clinical settings.
Article Synopsis
- Patch test outcomes can be affected by age, but there are mixed findings on how age impacts these results.
- The study involved over 13,000 patients and revealed that middle-aged adults (31-65 years) had the highest rates of positive skin sensitisation results, particularly for certain substances like nickel and potassium dichromate.
- Overall, while age does influence some patch test results, most allergens showed consistent reactivity across ages, underscoring the importance of standard testing regardless of age.
Recurrent aphthous stomatitis in a child successfully treated with apremilast.
Pediatr Dermatol
September 2024
Article Synopsis
- A 13-year-old boy had recurrent canker sores for two years, which didn’t improve with previous treatments.
- He started treatment with apremilast, a medication that showed positive results.
- This case is notable as it's the first documented instance of a pediatric patient being treated with apremilast for canker sores.
Article Synopsis
- B-cell epidermotropism is a rare occurrence in skin lymphomas, typically seen in systemic lymphomas like splenic marginal zone lymphoma.
- This type of lymphoma can present with skin symptoms before other signs, such as an enlarged spleen, and may involve bone marrow or blood.
- The case discussed highlights the importance for clinicians to recognize this feature, as it may indicate further disease spread and necessitate more thorough initial staging.
Interleukin (IL)-9 is present in atopic dermatitis (AD) lesions and is considered to be mainly produced by skin-homing T cells expressing the cutaneous lymphocyte-associated antigen (CLA). However, its induction by AD-associated triggers remains unexplored. Circulating skin-tropic CLA and extracutaneous/systemic CLA memory T cells cocultured with autologous lesional epidermal cells from AD patients were activated with house dust mite (HDM) and staphylococcal enterotoxin B (SEB).
View Article and Find Full Text PDFBackground: Frequent attendance is a common issue for primary care health centres. The phenomenon affects the quality of care, increases doctors' workloads and can lead to burnout.This study presents the results of an educational intervention for primary care physicians, aimed at helping them to decrease the prevalence rate of excessive attendance by patients at their centres.
View Article and Find Full Text PDFBackground: Topical imiquimod has been shown to be an effective treatment for extramammary Paget disease (EMPD), although available evidence supporting its use is based on case reports and small series of patients.
Objectives: To investigate the therapeutic outcomes and analyse potential clinicopathological factors associated with the imiquimod response in a large cohort of patients with EMPD.
Methods: Retrospective chart review of 125 patients with EMPD treated with imiquimod at 20 Spanish tertiary-care hospitals.
Article Synopsis
- A multicentric study in Spain analyzed data from 10,176 patients over four years to explore polysensitization (PS), finding that 8.3% of participants were polysensitized.
- Factors associated with PS included older age, atopic dermatitis, and exposure at specific body locations, with significant differences in allergen relevance compared to those with fewer sensitivities.
- The research revealed distinct allergen clusters among polysensitized patients, suggesting that cross-reactivity and sensitization may contribute to these patterns.
An 11-year-old boy presented generalized eruptive syringomas (ESs) associated with multiple milia-like whitish palmar papules corresponding to dermal calcium deposits. A relationship between calcium deposits distribution to an underlying eccrine duct was noted on pathology. The observation of dermal calcium deposits and its association with generalized ESs may support a possible sweat duct origin of this uncommon and peculiar form of superficial calcinosis cutis.
View Article and Find Full Text PDFArticle Synopsis
- Solar urticaria is a rare skin condition triggered by sunlight, affecting 41 patients in a study that analyzed long-term outcomes and treatment approaches, particularly with omalizumab over 16 years.
- The study found that treating patients with omalizumab resulted in significant improvements in symptoms, as indicated by decreased levels of the high-affinity IgE receptor (FcεRI) and enhanced Urticaria Control Test scores.
- Despite a high drug survival rate of 88.9% at 48 months, only one patient successfully discontinued omalizumab on a stepping-down protocol, suggesting that ongoing monitoring and treatment may be necessary for most patients.
Background: Previous investigations pointed out a role for antigen stimulation in Sezary syndrome (SS). High-throughput sequencing of the T cell receptor (TR) offers several applications beyond diagnostic purposes, including the study of T cell pathogenesis.
Methods: We performed high-throughput RNA sequencing of the TR alpha (TRA) and beta (TRB) genes focusing on the complementarity-determining region 3 (CDR3) in 11 SS and one erythrodermic mycosis fungoides (MF) patients.
Background: Autoimmunity contributes to the pathogenesis of chronic spontaneous urticaria (CSU). The subtyping of CSU has revealed an autoimmune form of CSU. Despite autoimmune diseases having been associated with CSU, there are few prospective studies that have evaluated the characteristics and biomarkers of patients with CSU and autoimmune disease in a real-life practice setting.
View Article and Find Full Text PDFBackground: Evidence regarding long-term therapeutic outcomes and disease-specific survival (DSS) in Extramammary Paget's disease (EMPD) is limited.
Objectives: To assess the DSS and outcomes of surgical and nonsurgical therapeutic modalities in a large cohort of EMPD patients.
Methods: Retrospective chart review of EMPD patients from 20 Spanish tertiary care hospitals.