Publications by authors named "Ramon Arroyo Ruiz"
Clinical and Genetic Characterization of a Cohort of Small-for-Gestational-Age Patients: Cost-Effectiveness of Whole-Exome Sequencing and Effectiveness of Treatment with GH.
Ramón Arroyo-Ruiz Cristina Urbano-Ruiz María Belén García-Berrocal Elena Marcos-Vadillo María Isidoro-García
J Clin Med
July 2024
Develop a clinical and genetic characterization, in a group of small-for-gestational-age (SGA) patients who did not experience catch-up growth In an ambispective cohort study with (SGA) patients. These patients received one treatment with growth hormone (GH) over 14 years. This study analyzes their response to treatment and conducts a genetic analysis in order to identify cases with specific phenotypic and auxological characteristics, defined as presenting two or more dysmorphic traits and/or a stature below -3 SDS (standard deviation score).
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- The study aimed to examine how effective recombinant human growth hormone (rhGH) is for children born small for gestational age (SGA) who don't experience catch-up growth, tracking their progress until they reach adult height.
- A total of 96 SGA patients were monitored over time, with 61 reaching adult height and showing significant gains, particularly in girls, while factors such as sex and initial height gain were identified as key predictors of treatment outcomes.
- The findings indicate that most SGA children achieve a height above -2 standard deviations, especially girls, and that height gain in the first year on treatment is crucial for predicting long-term growth success, although boys tend to have lower overall height gains during puberty.