Susceptibility genetic variants associated with colorectal cancer risk correlate with cancer phenotype.

Background & Aims: Ten common low-penetrant genetic variants have been consistently associated with colorectal cancer (CRC) risk; little is known about the correlation between these variants and CRC phenotype. Characterization of such a correlation would improve CRC management and prevention programs. We assessed the association between these genetic variants and CRC phenotype in patients and modeled pairwise combinations to detect epistasis.

[Endoscopic treatment of Zenker's diverticulum].

Introduction: We report our experience in the endoscopic (flexible) treatment of Zenker's diverticulum.

Patients And Method: Three patients with medium-sized Zenker's diverticula were treated by endoscopic cricopharyngeal myotomy with a modified needle-knife sphincterotome through a therapeutic gastroscope. The procedure was performed in the digestive endoscopy unit under conscious sedation without anesthetic support.