Uncovering system-specific stress signatures in primate teeth with multimodal imaging.

Early life stress can disrupt development and negatively impact long-term health trajectories. Reconstructing histories of early life exposure to external stressors is hampered by the absence of retrospective time-specific biomarkers. Defects in tooth enamel have been used to reconstruct stress but the methods used are subjective and do not identify the specific biological systems impacted by external stressors.

Comparative clinical study of coronally advanced flap with and without use of plasma rich in growth factors in the treatment of gingival recession.

Purpose: To evaluate the clinical efficiency of the coronally advanced flap (CAF) with and without plasma rich in growth factors (PRGF) in the management of gingival recession defects.

Methods: 20 bilateral similar recession defects in six healthy non-smoker subjects were included in the present study. The test sites received PRGF as an adjunct to the coronally advanced flap (CAF) while the control sites were treated with CAF only.

Formocresol versus calcium hydroxide direct pulp capping of human primary molars: two year follow-up.

Objectives: Clinical and radiographic evaluation of the premedicated direct pulp capping using formocresol (PDC) versus conventional direct pulp capping using calcium hydroxide (CDC) in human carious primary molars.

Study Design: A total of 120 vital primary molars with pinpoint exposure during caries removal in 84 patients aged 4-5 years were selected. In the PDC group (n = 60), 20% Buckley's formocresol solution, and in the CDC group (n = 60), calcium hydroxide powder were applied to the exposure sites followed by placement of zinc oxide-eugenol base.

Dental treatment duration as an indicator of the behavior of 3-to 9-year-old pediatric patients in clinical dental settings.

Aim: The aim of this study was to evaluate the age-specific effect of treatment duration on pediatric patient behavior.

Methods And Materials: A total of 450 children 3 to 9 years of age were allocated into six consecutive age groups (n=75 for each group). All children received dental treatment procedures which included the fabrication of a Type 1 composite resin restoration, then a dental prophylaxis followed by fluoride therapy with each procedure requiring an average of 20 minutes.

The efficacy of a modified omega wire extension for the treatment of severely damaged primary anterior teeth.

Objectives: The restoration of the severely damaged anterior teeth is considered a serious challenge in contemporary dental practice. The aim of the present study was the clinical and radiographic evaluation of a modified omega loop technique for the restoration of the severely damaged primary anterior teeth.

Study Design: A total of 144 anterior teeth in 60 healthy children (male: 32, female: 28) aged 3-4 years, severely damaged by dental caries, were included in the present study.

Site-specificity of pain sensitivity to intraoral anesthetic injections in children.

A total of 455 children (242 males and 213 females) aged 5-6 years were investigated for their pain reactions to maxillary and mandibular infiltration anesthesia, middle superior alveolar nerve block, posterior superior alveolar nerve block, greater palatine nerve block, nasopalatine nerve block, and inferior alveolar nerve block, and the responses were quantified using the sound, eye and motor (SEM) scale. Administration of nasopalatine nerve block produced maximum pain (median SEM score: 10) while that of posterior superior alveolar nerve block and inferior alveolar nerve block was accompanied by minimum pain (3 and 4, respectively). There was no significant gender-specific difference in pain reactions (P = 0.

The effect of pre-cooling the injection site on pediatric pain perception during the administration of local anesthesia.

Aim: The aim of the study was to evaluate the effect of cooling the soft tissue of injection sites on the pain perceptions of pediatric patients during the administration of local anesthesia for routine dental procedures.

Methods And Materials: A total of 160 children aged 5-6 years were included in the present study. On a random basis, the subjects were allocated to the without ice pretreatment (WIP) group (topical anesthesia + counterstimulation + distraction) or the ice pretreatment (IP) group (cooling + topical anesthesia + counterstimulation + distraction).

Apgar index as a correlate of enamel defects of primary dentition.

Purpose: Enamel defects are serious challenges because of their unaesthetic appearance, dentinal sensitivity and the subsequent susceptibility to dental caries. Apgar index (AI) is used for postnatal, general, neural and behavioural assessment of newborns. The aim of the present study was to investigate the correlation of AI with the enamel defects of primary dentition.

Lingual eruption of mandibular permanent incisors: a space correlated phenomenon?

Aim: The aim of the present study was to investigate the prevalence and distribution according to various arch length conditions of lingually erupted mandibular permanent incisors and the effect of space condition on this phenomenon with long-term follow-up of these teeth.

Methods And Materials: A total of 105 children aged 5-7.5 years with one or more permanent mandibular incisors erupting lingual to the corresponding primary incisors were included in the study.

The efficacy of distraction and counterstimulation in the reduction of pain reaction to intraoral injection by pediatric patients.

Aim: The aim of this clinical investigation was to determine the efficacy of distraction and counterstimulation in the reduction of pain during the administration of local anesthetics in pediatric dental patients.

Methods And Materials: A total of 78 healthy children (male: 40, female: 38) ages four to five years (mean age: 4.72 years old) without any history of previous intraoral injection were included in the present study.

Trigeminal trophic syndrome with features of oral CMV disease.

Trigeminal trophic syndrome (TTS) is an exceedingly rare complication following injury to the trigeminal ganglion, characterized by painless ulcerations, which has only rarely been reported with intraoral features. We present a patient with multiple intraoral ulcerations of the right buccal and alveolar mucosa that had previously been treated with nerve ablation therapy for trigeminal neuralgia. Positive immunohistochemistry staining of a biopsy specimen for cytomegalovirus suggested a viral etiology; however, lesions persisted despite antiviral therapy, and immunohistochemistry was negative on follow-up biopsy.

A clinical study of formocresol pulpotomy versus root canal therapy of vital primary incisors.

Objectives: Pulpotomy of primary incisors is a serious challenge due to the lack of a distinct boundary between the coronal and the radicular pulp and the inaccuracy of the clinical indication criteria. The aim of the present study is the clinical and radiographic evaluation of pulpotomy versus root canal therapy (RCT) of vital primary incisors.

Study Design: A total of 100 incisors in 50 patients (female: 27, male: 23) aged 3-4 years were allocated to formocresol pulpotomy (45 teeth) and RCT (46 teeth) using zinc oxide-eugenol.

Correlation of parenting style and pediatric behavior guidance strategies in the dental setting: preliminary findings.

Objective: The aim of this study was to investigate the influence of parenting style on the choice of proper behavior guidance strategies in pedodontics.

Material And Methods: Seventy-two children aged between 4 and 6 years (mean 5.12 years) with carious primary mandibular molars were selected.

Study of root canal accessibility in human primary molars.

The aim of the present study was to provide a general scheme for pulpectomy of primary molars that may be useful for decision-making about negotiation of root canals and selection of appropriate instruments. A total of 160 vital primary molars in 85 patients (40 males, 45 females) aged 4-6 years were selected. After taking primary radiographs, local anesthesia was induced, and the teeth were isolated using a rubber dam.

Malignant fibrous histiocytoma of the mandible in the context of a traumatic Marjolin's ulcer.

We present a rare manifestation of a chronic mandibular wound with a traumatic diathesis. A 38-year-old male patient sought medical consultation because of painless swelling in the mandibular symphysis and mild paresthesia of the lower lip. He mentioned a history of physical trauma to the mandibular symphysis 12 months ago.

Effect of cigarette smoke exposure on the growth of Streptococcus mutans and Streptococcus sanguis: an in vitro study.

The aim of the present study was to determine the effect of cigarette smoke on the growth of Streptococcus mutans and Streptococcus sanguis. The standard strains of S. mutans (ATCC 25175) and S.

Triad of bilateral duplicated permanent teeth, persistent open apex, and tooth malformation: a case report.

Aim: The aim of this article is to report a case of bilateral multiple impacted supernumerary teeth. A discussion of possible mechanisms of development is also presented along with a concise review of the literature.

Background: Supernumerary teeth occur in the context of various scenarios in the primary and the permanent dentition.

Phenobarbital-induced gingival hyperplasia.

Aim: The aim of this article is to present a case of a phenobarbital-induced gingival hyperplasia (GH), discuss possible etiological mechanisms of drug-induced GH, and to present a concise review of the literature.

Background: GH is a well-known complication associated with anticonvulsant phenytoin, antihypertensive calcium channel blockers, and immunosuppressant cyclosporine therapy. Sodium valproate and primidone has very rarely been found to cause GH.

Superficial topography of wound: a determinant of underlying biological events?

Three-dimensional configuration of wounds varies considerably according to the etiology. Wounding of skin is proceeded by release of dermal pretension. Subsequent disruption of physical equilibrium with resulting development of force vectors alters the primary shape of wound to maintain a new dynamic physical equilibrium.

Fluoxetine enhances cutaneous wound healing in chronically stressed Wistar rats.

Objectives: To evaluate the histologic and clinical effects of fluoxetine administration on wound healing in chronically stressed and nonstressed Wistar rats.

Study Design: Full-thickness incisional wounds were created on the lower back of 72 female Wistar rats. Animals were divided into 2 stress and nonstress groups according to application of stress regimen and 3 subdivisions based on placebo, acute, or chronic administration of fluoxetine.