Publications by authors named "Ramil E Sapinoro"
Article Synopsis
- Cigarette smoke triggers strong inflammation leading to lung diseases like COPD, and resolution of this inflammation is an active process, involving specialized lipid mediators derived from omega-3 and omega-6 fatty acids.
- RvD1, a specific lipid mediator, shows potential in reducing inflammation in lung models by suppressing harmful pro-inflammatory substances and enhancing protective factors, both during and after exposure to cigarette smoke.
- The study's findings suggest that RvD1 could be a valuable therapeutic agent for managing lung inflammation linked to smoking, promoting quicker recovery by fostering anti-inflammatory responses and beneficial macrophage activities.
Acute and chronic lung inflammation is associated with numerous important disease pathologies including asthma, chronic obstructive pulmonary disease and silicosis. Lung fibroblasts are a novel and important target of anti-inflammatory therapy, as they orchestrate, respond to, and amplify inflammatory cascades and are the key cell in the pathogenesis of lung fibrosis. Peroxisome proliferator-activated receptor gamma (PPARγ) ligands are small molecules that induce anti-inflammatory responses in a variety of tissues.
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- TG2 (Transglutaminase 2) plays a significant role in the progression of idiopathic pulmonary fibrosis (IPF), a severe lung disease with limited treatment options.
- The study showed that mice lacking TG2 had notably less fibrosis compared to normal mice, indicating TG2's involvement in the disease's fibrotic response.
- In human samples, TG2 was found to be more active in IPF patients, suggesting it contributes to fibrotic processes and could be a potential target for new therapies.