Publications by authors named "Rameshwar Nk Bamezai"
Article Synopsis
- Triple-negative breast cancer (TNBC) is known for its aggressiveness and lack of effective treatments, making it a challenging condition to manage.
- Research shows that silibinin disrupts metabolic processes in TNBC cells by targeting the EGFR-MYC-TXNIP signaling pathway, leading to reduced cell growth and survival.
- Combining silibinin with traditional chemotherapy drugs like paclitaxel appears to enhance anti-cancer effects, suggesting that targeting metabolic pathways could be a promising approach for treating TNBC.
Tyrosine phosphorylation (p-Y105) of pyruvate kinase (PK) M2, in recent years, has been suggested to facilitate Warburg effect and tumor cell growth. However, a comparison of the structural dynamics of the un-phosphorylated, the active, and the phosphorylated-at-Y105, the inactive-states, is not clear. We studied molecular dynamics of the two states to unravel these features, where phosphorylated PKM2 showed a rapid global conformation change in the initial stages of the simulation.
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