Publications by authors named "Ramesha Hanumanthappa"
The prevalence of diabetes has reached alarming levels in India, making it essential to understand the concentration of nutritional-trace elements (Fe, Cu, Zn, Cr. and Se) in blood samples from diabetic adults. In this study, 208 whole blood samples from diabetic (n = 104) and non-diabetic (n = 104) adults across various age groups were analyzed using total reflection X-ray fluorescence (TXRF) spectroscopy with a sample dilution method.
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- Parkinson's disease (PD) is a progressive condition marked by the loss of dopamine-producing neurons, which leads to various movement difficulties and other symptoms.
- Pramipexole (PPX) is a drug used for PD treatment, but it has limitations such as a short half-life and side effects, prompting research into enhanced formulations like PPX-loaded nanoparticles.
- The study developed a new biodegradable nanoparticle complex (PPX-PVP-CuO NC) that significantly improved treatment outcomes in a PD model by enhancing behavior and reducing oxidative stress markers, suggesting it could be a promising therapeutic option for managing PD.