Real-Time Intraoperative Detection of Margins for Oral Cavity Squamous Cell Carcinoma.

Obtaining negative surgical cancer margins is the strongest predictor for the long-term survival of oral cavity squamous cell carcinoma patients. To verify that the tumor has been completely removed, surgeons rely on pathologic evaluation of frozen sections to determine surgical margins, which can be time-consuming and subjective. Herein, we detail the real-time intraoperative use of dynamic optical contrast imaging (DOCI), a novel imaging modality that rapidly distinguishes head and neck cancer from healthy adjacent tissues based on fluorescence decay information from spectral bands in the UV-VIS range.

Label-free, real-time detection of perineural invasion and cancer margins in a murine model of head and neck cancer surgery.

Surgical management of head and neck cancer requires a careful balance between complete resection of malignancy and preservation of function. Surgeons must also determine whether to resect important cranial nerves that harbor perineural invasion (PNI), as sacrificing nerves can result in significant morbidity including facial paralysis. Our group has previously reported that Dynamic Optical Contrast Imaging (DOCI), a novel non-invasive imaging system, can determine margins between malignant and healthy tissues.

Ex vivo hypercellular parathyroid gland differentiation using dynamic optical contrast imaging (DOCI).

Primary hyperparathyroidism, often caused by a single adenoma (80-85%) or four-gland hyperplasia (10-15%), can lead to elevated parathyroid hormone (PTH) levels and resultant hypercalcemia. Surgical excision of offending lesions is the standard of care, as the removal of pathologic adenomas reduces PTH and calcium values to baseline. The small size, variable location, and indistinct external features of parathyroid glands can make their identification quite challenging intraoperatively.

A Tool to Locate Parathyroid Glands Using Dynamic Optical Contrast Imaging.

Objectives/hypothesis: Identification of parathyroid glands and adjacent tissues intraoperatively can be quite challenging because of their small size, variable locations, and indistinct external features. The objective of this study is to test the efficacy of the dynamic optical contrast imaging (DOCI) technique as a tool in specifically differentiating parathyroid tissue and adjacent structures, facilitating efficient and reliable tissue differentiation.

Study Design: Prospective study.

Lasing characteristics of Ho:YAG single crystal fiber.

Lasing was demonstrated for the first time at 2.09 μm in 0.5% Holmium (Ho) doped YAG single crystal fiber (SCF) fabricated using the Laser Heated Pedestal Growth (LHPG) method.

Concentric vortex beam amplification: experiment and simulation.

The amplification of a 2 μm concentric vortex beam in a Ho:YAG crystal rod amplifier is simulated and experimentally verified. Different concentric vortex beams are studied and the amplification results are compared with simulation. The integrity of the launched vortex beams is well maintained through the amplification process.

Highly efficient ytterbium-doped phosphosilicate fiber lasers operating below 1020 nm.

Highly-efficient high-power fiber lasers operating at wavelength below 1020 nm are critical for tandem-pumping in >10 kW fiber lasers to provide high pump brightness and low thermal loading. Using an ytterbium-doped-phosphosilicate double-clad leakage-channel fiber with ~50 µm core and ~420 µm cladding, we have achieved ~70% optical-to-optical efficiency at 1018 nm. The much larger cladding than those in previous reports demonstrates the much lower required pump brightness, a key for efficient kW operation.

Ho:YAG single crystal fiber: fabrication and optical characterization.

0.5% Holmium (Ho) doped YAG single crystal fiber (SCF) was fabricated using Laser Heated Pedestal Growth (LHPG) method and characterized for its optical absorption and emission properties involving transitions between the 5I8 and 5I7 energy levels. The results verified the absorption peaks suitable for in-band direct pumping at 1908 nm and 1932 nm with the emission occurring between 2050 and 2150 nm.

Discrete cylindrical vector beam generation from an array of optical fibers.

A novel method is presented for the beam shaping of far field intensity distributions of coherently combined fiber arrays. The fibers are arranged uniformly on the perimeter of a circle, and the linearly polarized beams of equal shape are superimposed such that the far field pattern represents an effective radially polarized vector beam, or discrete cylindrical vector (DCV) beam. The DCV beam is produced by three or more beams that each individually have a varying polarization vector.

Mechanism of water augmentation during IR laser ablation of dental enamel.

Background And Objectives: The mechanism of water augmentation during IR laser ablation of dental hard tissues is controversial and poorly understood. The influence of an optically thick applied water layer on the laser ablation of enamel was investigated at wavelengths in which water is a primary absorber and the magnitude of absorption varies markedly.

Study Design/materials And Methods: Q-switched and free running Er: YSGG (2.