Cassia tora extract alleviates Aβ aggregation processes in vitro and protects against aluminium-induced neurodegeneration in rats.

Objectives: To examine the ability of Cassia tora extract to produce, in vitro and in vivo, beneficial effects with respect to events occurring during Alzheimer's disease.

Methods: Previously characterised methanol extract of C. tora was tested for its ability to lessen Aβ aggregation processes in vitro and to alleviate aluminium-induced impairments in vivo in rats.

Cassia tora prevents Aβ aggregation, inhibits acetylcholinesterase activity and protects against Aβ-induced cell death and oxidative stress in human neuroblastoma cells.

Background: Alzheimer's is a complex neurodegenerative disease and is characterized by extraneuronal accumulation of β-amyloid peptide. Because of its complex nature, multi-target directed ligands (MTDLs) are increasingly being considered as promising anti-Alzheimer therapeutic agents. This study is aimed at determining the effects of Cassia tora ethyl acetate fraction on several Alzheimer-associated deleterious events in test tubes as well as in human neuroblastoma SK-N-SH and SH-SY5Y cell lines.

Neuro-nutrients as anti-alzheimer's disease agents: A critical review.

Alzheimer's disease (AD) is characterized by a massive neuronal death causing memory loss, cognitive impairment and behavioral alteration that ultimately lead to dementia and death. AD is a multi-factorial pathology controlled by molecular events such as oxidative stress, protein aggregation, mitochondrial dysfunction and neuro inflammation. Nowadays, there is no efficient disease-modifying treatment for AD and epidemiological studies have suggested that diet and nutrition have a significant impact on the development of this disorder.

Multiple pharmacological activities of Caesalpinia crista against aluminium-induced neurodegeneration in rats: Relevance for Alzheimer's disease.

Alzheimer's disease (AD) is the most common form of dementia and mainly affects cognitive function of the aged populations. Aluminium, a neurotoxic metal, has been suggested as a contributing factor of AD. Caesalpinia crista is a medicinal plant known for its anti-microbial, anti-inflammatory and anti-oxidant properties.

Linn. Induces Protection against DNA and Membrane Damage.

Background: is a medicinal herb used to cure various ailments in subtropical and tropical regions of Southeast Asia.

Objective: The objective of this evaluation of against free radical induced DNA and erythrocyte damage.

Materials And Methods: The profiles of polyphenol and flavonoid were quantified through reversed-phase high-performance liquid chromatography.

Neuroprotective effects of Cassia tora against paraquat-induced neurodegeneration: relevance for Parkinson's disease.

The aim of the present study was to determine whether Cassia tora extracts could reverse the oxidative stress-induced neurodegeneration in a Parkinson's disease in vitro model. The leaves were treated with ethyl acetate (CtEA) or methanol (CtME). The extracts were first analysed by HPLC for their phenolic content and then tested for their neuroprotective effects in human SK-N-SH neuroblastoma cells.

Evaluation of Linn. against Oxidative Stress-induced DNA and Cell Membrane Damage.

Objective: The present study aims to evaluate antioxidants and protective role of Linn. against oxidative stress-induced DNA and cell membrane damage.

Materials And Methods: The total and profiles of flavonoids were identified and quantified through reversed-phase high-performance liquid chromatography.

Activation of α-secretase by curcumin-aminoacid conjugates.

The extracellular senile plaques observed in Alzheimer's disease (AD) patients are mainly composed of amyloid peptides produced from the β-amyloid precursor protein (βAPP) by β- and γ-secretases. A third non-amyloidogenic α-secretase activity performed by the disintegrins ADAM10 and ADAM17 occurs in the middle of the amyloid-β peptide Aβ and liberates the large sAPPα neuroprotective fragment. Since the activation of α-secretase recently emerged as a promising therapeutic approach to treat AD, the identification of natural compounds able to trigger this cleavage is highly required.

Molecular studies on Abeta(42) induced genomic instability in aged rabbit brain.

DNA stability and conformation are important in the life cycle of an organism. The DNA instability is postulated to be one of the risk factors for neuronal death in neurodegenerative disorders. Among all other risk factors, amyloid is one of the most important risk factor for neurodegeneration.