Publications by authors named "Ramayee Periakaruppan"
Lynch syndrome is an autosomal dominant disorder, caused by an abnormality in DNA mismatch repair genes and characterized by the development of a variety of cancers. Upper urinary tract urothelial carcinoma is well characterized in Lynch syndrome; however, support for the inclusion of bladder urothelial carcinoma is limited, except for MSH2 mutation carriers. Urologic adenocarcinoma has not been documented in Lynch syndrome.
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- The development of resistance to platinum drugs, particularly in ovarian cancer, is a major challenge for effective treatment, and altered pH levels in tumor cells contribute to this resistance.
- The study reveals that V-ATPase-V0a2, a specific proton pump isoform, is over-expressed in cisplatin-resistant ovarian cancer cells, facilitating tumor invasion through acidification and immune modulation.
- Targeting V-ATPase-V0a2 can enhance the sensitivity of these resistant tumors to cisplatin and carboplatin, potentially offering a new therapeutic approach by reducing pH levels and improving DNA damage response.
Cerebral aspergillosis is a rare and highly fatal hematogenous infection most commonly found in immune compromised patients. From the onset of neurologic symptoms, the median reported rate of survival is between 5 and 9 days. Compounded with increased hemorrhagic risks and the lack of specificity in both clinical presentation and traditional imaging, a fast and noninvasive method of definitive diagnosis is necessary if there is to be any hope for positive outcomes.
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