Physician Reasons for or Against Treatment Intensification in Patients With Metastatic Prostate Cancer.

Importance: Clarifying the underutilization of treatment intensification (TI) for metastatic castration-sensitive prostate cancer (mCSPC) may improve implementation of evidence-based medicine and survival outcomes.

Objective: To investigate physicians' beliefs about TI in mCSPC to understand the gap between evidence-based guidelines and clinical practice.

Design, Setting, And Participants: This survey study analyzed data from the Adelphi Real World retrospective survey, which comprised physician surveys that were linked to medical record reviews of US adult patients treated for mCSPC between July 2018 and January 2022.

Studying the properties of green synthesized silver oxide nanoparticles in the application of organic dye degradation under visible light.

In present study the green synthesis of silver oxide nanoparticles has been effectively achieved using novel plant extract Phragmanthera Macrosolen. This method provides sustainable alternative for nanoparticle synthesis, demonstrating the potential of Phragmanthera Macrosolen as a reducing and stabilizing agent in the production of AgO NPs. The synthesized nanoparticles were characterized for their structural, morphological, and optical properties, confirming their successful formation and potential applications in various fields.

Exploring current conduction dynamics in multiferroic BiFeO thin films prepared via modified chemical solution method.

The current study describes current conduction mechanisms in BiFeO thin films prepared by using a modified chemical solution-based technique. In particular, in these films, X-ray photoelectron spectroscopy revealed that the defect causing Fe ions reduced by about 18% compared to the solution-based synthesis methods reported before, indicating better film quality. The leakage current density was measured to be 1.

Isolation, characterization and antimicrobial activity study of Thymus vulgaris.

Herbal medicines are important for ensuring sustainable development goals (SDGs) in healthcare, particularly in developing countries with high rates of antimicrobial resistance (AMR) and little access to medical facilities. Thymus vulgaris is a widely used herbal medicinal plant known for its secondary metabolites and antimicrobial properties. The present study involved a comprehensive examination of the isolation, characterization, and antibacterial activity of Thymus vulgaris obtained from Ethiopia.

Spatial analysis and assessment of soil erosion in the southern Western Ghats region in India.

Soil erosion is expected to worsen in the future as a result of climate change, growing population demands, improper land use, and excessive exploitation of natural resources in India. Due to the growing population and changes in land use, it has become increasingly crucial to map and quantitatively assess soil for the purpose of sustainable agricultural usage and planning conservation efforts. The problem of soil erosion is mainly on steeper slopes with intense rainfall in parts of Western Ghats.

Phytochemical profiling and antioxidant evaluation of Sm leaf and flower: integrative analysis using advanced analytical techniques.

Objective: This study investigates the biological activities of Sm from the eastern Himalayas, addressing a literature gap on its properties. It explores the plant's phytochemical, antioxidant, and medicinal characteristics.

Significance: Evaluating methanolic extracts of offers valuable insights into its bioactive potential.

Treatment patterns and outcomes in patients with nonmetastatic castration-resistant prostate cancer in the United States.

Androgen receptor pathway inhibitors (ARPIs) prolong metastasis-free survival and overall survival in patients with nonmetastatic castration-resistant prostate cancer (nmCRPC). This study aimed to evaluate real-world treatment patterns, utilization and survival outcomes in patients with nmCRPC. This retrospective cohort study used Optum database electronic health records of patients with nmCRPC from 1 January 2007 to 31 December 2020 in the US.

Biosynthesis of TiO nano particles by using Rosemary (Rosmarinus officinalis) leaf extracts and its application for crystal dye degradation under sunlight.

Titanium dioxide (TiO) nanoparticles were prepared through Rosmarinus-officinalis leaf extracts at 90 and 200°C. In this research, the degradations of methylene blues by using TiO nanoparticles Sun light radiations were studied. The synthesized materials were characterized using XRDs, UV-Vis, PL, SEM, TEM, EDS and XPS.

Investigating topic modeling techniques through evaluation of topics discovered in short texts data across diverse domains.

The online channel has affected many facets of an individual's identity, commercial, social policy, and culture, among others. It implies that discovering the topics on which these brief writings are focused, as well as examining the qualities of these short texts is critical. Another key issue that has been identified is the evaluation of newly discovered topics in terms of topic quality, which includes topic separation and coherence.

Emerging racial disparities among Medicare beneficiaries and Veterans with metastatic castration-sensitive prostate cancer.

Background: Previous studies have shown that Black men receive worse prostate cancer care than White men. This has not been explored in metastatic castration-sensitive prostate cancer (mCSPC) in the current treatment era.

Methods: We evaluated treatment intensification (TI) and overall survival (OS) in Medicare (2015-2018) and Veterans Health Administration (VHA; 2015-2019) patients with mCSPC, classifying first-line mCSPC treatment as androgen deprivation therapy (ADT) + novel hormonal therapy; ADT + docetaxel; ADT + first-generation nonsteroidal antiandrogen; or ADT alone.

Real-world overall survival with abiraterone acetate versus enzalutamide in chemotherapy-naïve patients with metastatic castration-resistant prostate cancer.

Background: There are no large head-to-head phase 3 clinical trials comparing overall survival (OS) for abiraterone and enzalutamide. This study used Medicare claims data to compare OS in patients with chemotherapy-naïve metastatic castration-resistant prostate cancer (mCRPC) who initiated abiraterone or enzalutamide.

Methods: This retrospective analysis of the Medicare database (2009-2020) included adult men with ≥1 claim for prostate cancer, metastatic diagnosis, and no prior chemotherapy or novel hormone therapy who initiated first-line (1L) abiraterone or enzalutamide in the index period (September 10, 2014 to May 31, 2017).

Outbreak of toxic anterior segment syndrome following vitreoretinal surgery - A retrospective analysis.

Background: Toxic anterior segment syndrome (TASS) is an uncommon complication of vitreoretinal surgery and is characterized by severe anterior chamber reaction, hypopyon, and limbus-to-limbus corneal edema.

Methods: Twenty-nine vitreoretinal surgeries were performed, of which 14 developed TASS in the early postoperative period. The operative records were reviewed retrospectively.

Mechanical power and normalized mechanical power in pediatric acute respiratory distress syndrome.

Background: Mechanical power (MP) refers to the energy transmitted over time to the respiratory system and serves as a unifying determinant of ventilator-induced lung injury. MP normalization is required to account for developmental changes in children. We sought to examine the relationship between mechanical energy (ME), MP normalized to body weight (MP), and MP normalized to respiratory compliance (MP) concerning the severity and outcomes of pediatric acute respiratory distress syndrome (pARDS).

Maintenance of crack with infilling polymer modified mortar for shear deficient of reinforced concrete beam.

Being a developing country, Pakistan needs sustainable and cost-effective strengthening/ retrofitting solution to be adopted/ practiced in the construction industry. The research reported in this paper was aimed to study the effectiveness of PMM, an indigenous product, for repairing reinforced concrete beams, resulting more effective and cost benefiting repair and strengthening for restoration of pre-cracked RC structures. This article presents the research results of experimental investigation conducted for repairing of cracks in shear deficient reinforced concrete (RC) beams with locally available novel material polymer modified mortar (PMM).

A vehicular network based intelligent transport system for smart cities using machine learning algorithms.

Smart cities and the Internet of Things have enabled the integration of communicating devices for efficient decision-making. Notably, traffic congestion is one major problem faced by daily commuters in urban cities. In developed countries, specialized sensors are deployed to gather traffic information to predict traffic patterns.

Numerical modelling on geotechnical features of soil mixture using recycled tire crumb to strengthen the seismic isolation in building.

In this research, the performance pertaining to tire crumb obtained from scrap tire processing plants is discussed. These tire crumbs are blended with soil at a 30% ratio. When subjected to seismic load, the performance of the 30% tire crumb combination is superior to the 0% tire crumb combination.

Effects of nanoadditives on the performance and emissions of rapeseed biodiesel in an insulated piston diesel engine.

Energy consumption and management have emerged as crucial production functions because of the high cost of energy. Since the total consumption of fossil fuels like diesel has increased proportionally to the expansion in demand for power generation, industry, and transportation services, researchers have long been interested in constructing a more energy-efficient engine. With its improved efficiency, reduced fuel consumption, and fewer emissions, the application of nano-coating technology to engine components has become more popular in recent years.

Selective isoxazolopyrimidine PAT1 (SLC26A6) inhibitors for therapy of intestinal disorders.

A loss of prosecretory Cl channel CFTR activity in the intestine is considered as the key cause of gastrointestinal problems in cystic fibrosis (CF): meconium ileus, distal intestinal obstruction syndrome (DIOS) and constipation. Since CFTR modulators have minimal effects on gastrointestinal symptoms, there is an unmet need for novel treatments for CF-associated gastrointestinal disorders. Meconium ileus and DIOS mainly affect the ileum (distal small intestine).

Seasonal variations in the phenolic profile, antioxidant activity, and mineral content of south Indian black tea (Camellia sinensis (L.) O. Kuntze).

In the Anamallais region of south India, crop shoots from the UPASI-3, UPASI-9, UPASI-17, Assam seedlings, and TRI-2043 cultivars were examined for seasonal variations in total phenolics, antioxidant activity, and minerals during four harvest seasons: summer (January to March), premonsoon (April and May), monsoon (June to September), and winter (October to December) of two consecutive years. The total phenolics of all cultivars were lower in monsoon period and grew over rest of the seasons and it was greater during summer. Crop shoot antioxidant activity as measured by the DPPH radical scavenging experiment exhibited a similar pattern to total phenolics.