Publications by authors named "Ramanpal Singh Makkad"

Article Synopsis
  • Oral lichen planus (OLP) is a chronic inflammatory illness that affects about 1-2% of adults, with a higher prevalence in middle-aged women, while hypothyroidism is a common endocrine condition seen in primary care.
  • A study aimed to compare the occurrence of OLP in patients with and without hypothyroidism involved 1200 patients, with equal groups of 600 each.
  • The results showed that 3.45% of those with hypothyroidism had OLP, compared to only 1.34% of those without, indicating a 2.37 times higher prevalence of OLP among individuals with hypothyroidism.
View Article and Find Full Text PDF
Article Synopsis
  • The study looked at how well different cleaning solutions kill germs and dissolve tooth tissue.
  • Researchers used 240 human teeth to test 6 different cleaning solutions and counted how many germs were left after.
  • The results showed that sodium hypochlorite (NaOCl) worked the best at killing bacteria and breaking down tooth tissue.
View Article and Find Full Text PDF

Background: Dental implants have been essential to the therapy of patients who are partially edentulous.

Aim: Clinical evaluation of the long-term survival and success rates of different types of implant-supported prostheses.

Materials And Methods: Patients who had a healthy edentulous ridge of three missing teeth in the posterior jaw in which two or three dental implants were placed having any of three prostheses, namely, three-unit fixed dental prostheses (FPD) on two implants, three splinted crowns on three implants, and three splinted crowns on three implants were included.

View Article and Find Full Text PDF

Background: Virtual surgical planning (VSG), also known as computer-assisted reconstruction, has started to become the norm for more complex patients in many centers in recent times.

Aim: This study was conducted to evaluate the VSG in maxillofacial reconstruction surgery.

Methods And Materials: This study included 20 patients who underwent surgery for maxillofacial reconstruction.

View Article and Find Full Text PDF

Background: Antimicrobial endodontic intracanal medicaments play a vital role along with biomechanical preparation in the elimination of bacteria present in the pulp area to achieve success in endodontic therapy.

Aim: The present research was conducted with the objective of evaluating and comparing intracanal medicaments regarding antibacterial properties against .

Materials And Methods: One hundred and twenty healthy human premolars of the mandible were used.

View Article and Find Full Text PDF
Article Synopsis
  • Genomic methylation shows promise as a tool for identifying oral potentially malignant disorders (OPMDS) and oral cancer, which could enhance understanding of cancer mechanisms and lead to new therapies.
  • A study involving 112 patients with premalignant and malignant oral lesions analyzed saliva samples to investigate genetic markers like p16, DAP-K, and MGMT using advanced DNA methylation technology.
  • Findings indicated that 12.7% of oral cancer lesions displayed methylation of the examined genes, with higher rates of co-methylation, suggesting these genetic markers can aid in predicting the progression of oral cancer and patient outcomes.
View Article and Find Full Text PDF
Article Synopsis
  • The study investigates the unexplained causes of oral lichen planus (OLP), which is linked to an immune response involving T-cells, by examining the role of oral microorganisms.
  • Researchers analyzed 82 tissue samples from OLP patients and 20 from healthy individuals using immunohistochemistry to identify specific microorganisms.
  • The findings revealed that various microorganisms, including certain periodontopathogenic bacteria and human papillomavirus types 16 and 18, were more frequently present in OLP patients than in healthy controls, suggesting a potential connection to the condition's development.
View Article and Find Full Text PDF
Article Synopsis
  • Genetic polymorphisms significantly impact human health, particularly in the context of diseases like oral submucous fibrosis (OSMF), a condition that can lead to cancer.
  • This study examined variations in cancer-metabolizing genes (CYP1A1 and GSTM1) in patients with OSMF, comparing genetic markers in patients with different stages of the condition and a control group.
  • Results indicated higher prevalence of specific gene polymorphisms in patients with OSMF and especially those with cancer, highlighting the crucial influence of these genetic variations on disease progression.
View Article and Find Full Text PDF

Background: Applying automated laser ablation procedures with pulsed, electronically administered diode laser equipment, and large-area masking results in highly aligned, uniform microstructures on these surfaces.

Aim: Clinical evaluation of role of laser in soft tissue surgical guide for implant placement.

Methods And Materials: This study included 30 patients with dental implants in their oral cavity.

View Article and Find Full Text PDF

Background: One emerging and important research method for biomechanical assessments in biological investigations is the finite element analysis (FEA). It is the best technique for simulating intricate structures and examining their mechanical characteristics.

Aim: This study was conducted to compare the V-shaped design and square thread design regarding their influence on the stress and strain distribution using the finite element method.

View Article and Find Full Text PDF

The salivary concentrations of alpha L fucosidase (AFU) and salic acid (SA) in oral submucous fibrosis patients and compare it with healthy controls is of interest to dentists. 40 patients of OSMF and 40 healthy controls were included. Estimation of AFU and SA in saliva and serum was carried out in every patient.

View Article and Find Full Text PDF

Herbal remedies have demonstrated remarkable effects as anti-diabetic, anticancer, antimicrobials, immunological modulatory agent in liver problems, respiratory illnesses, and as beauty agents. The need for more affordable, readily accessible, and alternative medicines has led to a rise in the recognition of herbal drugs. Therefore, it is of interest to evaluate and compare the effectiveness of photosensitized curcumin fibers, Aloevera, Amla Juice and Pancha Tulsi in disinfecting guttapercha (GP) cones.

View Article and Find Full Text PDF

Light Amplified Stimulated Emission of Radiation (LASER) is nowadays widely studied regarding their use in endodontics and restorative dentistry. Therefore, it is of interest to evaluate the antibacterial activity of three types of LASERs namely CO2 LASER.Er, Cr:YSGG LASER and Diode LASER in disinfection of root canals.

View Article and Find Full Text PDF

Aim: The research project focuses on the creation and assessment of an innovative computer vision system designed to identify dental irregularities in individuals undergoing orthodontic treatment.

Materials And Methods: To establish the computer vision system, a comprehensive dataset of dental images was collected, encompassing various orthodontic cases. The system's algorithm was trained to recognize patterns indicative of common dental anomalies, such as malocclusions, spacing issues, and misalignments.

View Article and Find Full Text PDF

Mini-screws, also known as temporary anchorage devices (TADs), offer enhanced control and versatility in orthodontic treatment by providing stable anchorage points. This clinical study aims to evaluate the effectiveness of mini-screw-supported molar intrusion in orthodontic practice. For this clinical study, a cohort of 40 orthodontic patients with various malocclusions requiring molar intrusion as part of their treatment plan was recruited.

View Article and Find Full Text PDF

The impact of 5.25 percent NaOCL on the resistance offered by TruNatomy, Hero Gold and ProtaperGold against cyclic fracture as against the treatment of NiTi rotary files with distilled water is of interest to dentists. Inside the stainless steel blocks, man-made canals were created for the purpose of testing the cyclic fatigue.

View Article and Find Full Text PDF

Three aesthetic indices namely aesthetic component of index of orthodontic treatment needs (IOTN -AC), dental aesthetic index (DAI) and dental aesthetics screening index (DESI) were compared in orthodontic treatment. 242 participants (160 female and 82 male) who were interested in orthodontic treatment participated. The individuals' ages ranged from 16-25 years.

View Article and Find Full Text PDF

Evaluation of immuno-histochemical (IHC) markers like p53, p63, PDPN, C-erb-B2, CK19, and VEGF in oral squamous cell carcinoma (OSCCs) is of interest to dentists. Sixty formalin-fixed paraffin embedded tissue blocks from the Department of Oral Pathology, New Horizon Dental College and Research, Institute, Sakri, Bilaspur, Chhattisgarh, India. The conventional IHC method was used to assess the expression of p53, p63, PDPN, C- erb-B2, CK19 and VEGF using the different antibodies.

View Article and Find Full Text PDF

Four surgical treatment modalities namely cryosurgery, scalpel and blade surgery, diode LASER surgery and CO2 LASER surgery in the management of oral potentially malignant disorders (OPMDs) in terms of healing outcomes post operatively and recurrence is evaluated. The study included sixty outpatients whose biopsies revealed OPMDs (oral lichen planus, homogeneous leukoplakia, non-homogenous leukoplakia and erythroplakia). There is decrease in post-operative pain and oedema in all four treatment categories at one week follow up and two week follow up.

View Article and Find Full Text PDF

Management of zygomatic complex fractures using closed reduction, two point open reduction with internal fixation (ORIF), closed reduction with three point ORIF and two point ORIF is of interest to dentist. 150 patients with zygomatic bone fractures between the ages of 14-60 years were included in the study. At final assessment, the percentage of stable condition was greater in closed reduction + two point ORIF and closed reduction + three point ORIF when compared to two point ORIF alone and three point ORIF alone and closed reduction alone.

View Article and Find Full Text PDF

The most frequent instrument used to begin tightening screws is a manually regulated screwdriver. Regarding manually regulated screwdrivers, predicted margins of error vary between fifteen percent to forty eight percent. Mechanical Torque restricting devices can consistently produce the requisite torques.

View Article and Find Full Text PDF

Background Gingivitis is a common oral health condition characterized by inflammation of the gingiva, which, if left untreated, can progress to more severe forms of periodontal disease. Effective oral hygiene practices play a crucial role in managing gingivitis, but the comparative efficacy of different oral hygiene aids remains unclear. This study aimed to evaluate and compare the efficacy of various oral hygiene aids in maintaining periodontal health in patients with gingivitis, considering gender and the degree of gingivitis as potential influencing factors.

View Article and Find Full Text PDF

When the duration of orthodontic treatment is shortened, the patient may have a number of benefits, including an increase in the number of dental cavities, root resorption, and gingival irritation, all of which are associated to a higher degree of decalcification. In addition to drugs, magnets, and other therapies, they include surgical methods (corticotomies, piezosurgery), mechanical/physical stimulation techniques (vibration, lasers), and other forms of therapy. These methods, each of which has been validated by extensive research, have been shown to reduce treatment times.

View Article and Find Full Text PDF

The impact of inflammatory response on the biological characteristics of GMSCs has been the subject of studies, with conflicting findings. In order to more fully understand the effects of the localized inflammatory environment, the current study assessed the intensity and differentiating capacity of GMSCs derived from healthy periodontal tissues (H-GMSC) and GMSC derived from inflamed periodontal tissues (I-GMSC) tissues. Cells from every well were taken out and counted using a hemocytometer every three days for a total of 12 days.

View Article and Find Full Text PDF

Endo-perio lesions involve a variety of therapy choices that will lead to the best possible elimination of infection. Various therapy approaches have been investigated for curing of patients affected by endo-perio abnormalities. One of the second-generation platelet derivatives is plasma enriched with platelet (PRP).

View Article and Find Full Text PDF