Publications by authors named "Ramanpal S Makkad"
Background: The concept of success is typically established by the researcher or the practitioner rather than the patient, who has the greatest stake in the outcome of the prosthodontics therapy.
Aim: To assess patient satisfaction and oral health-related quality of life (OHRQoL) in following full mouth rehabilitation with implant-supported prostheses (ISP).
Methods And Materials: Thirty-two patients who underwent full mouth rehabilitation with ISP were included in this study.
Article Synopsis
- Oral lichen planus (OLP) is a chronic inflammatory illness that affects about 1-2% of adults, with a higher prevalence in middle-aged women, while hypothyroidism is a common endocrine condition seen in primary care.
- A study aimed to compare the occurrence of OLP in patients with and without hypothyroidism involved 1200 patients, with equal groups of 600 each.
- The results showed that 3.45% of those with hypothyroidism had OLP, compared to only 1.34% of those without, indicating a 2.37 times higher prevalence of OLP among individuals with hypothyroidism.
Article Synopsis
- The study looked at how well different cleaning solutions kill germs and dissolve tooth tissue.
- Researchers used 240 human teeth to test 6 different cleaning solutions and counted how many germs were left after.
- The results showed that sodium hypochlorite (NaOCl) worked the best at killing bacteria and breaking down tooth tissue.
Periodontitis, a prevalent chronic inflammatory condition affecting the supporting structures of teeth, is closely associated with oxidative stress, characterized by an imbalance between reactive oxygen species generation and antioxidant defense mechanisms. Antioxidants have garnered significant attention as potential therapeutic agents in periodontal management due to their ability to counteract oxidative damage and inflammation. This brief review provides an overview of the role of antioxidants in periodontitis, highlighting recent developments.
View Article and Find Full Text PDFBackground: Dental implants have been essential to the therapy of patients who are partially edentulous.
Aim: Clinical evaluation of the long-term survival and success rates of different types of implant-supported prostheses.
Materials And Methods: Patients who had a healthy edentulous ridge of three missing teeth in the posterior jaw in which two or three dental implants were placed having any of three prostheses, namely, three-unit fixed dental prostheses (FPD) on two implants, three splinted crowns on three implants, and three splinted crowns on three implants were included.
Background: Attempts should be made to identify the molecule-based biomarkers, which give indication about the progression of precancer and malignancy of the oral area.
Aim: To evaluate the reliability of methylation of genes of saliva like P16, MGMT, and DAP-K as biomarkers for diagnosis of oral squamous cell carcinoma.
Methods And Materials: This study included 30 cases of histopathologically proven cases of oral squamous cell carcinoma.
Background: The process of curing and regaining the integrity of damaged tissues is known as healing. An autologous concentration of platelets embedded in plasma is known as platelet-rich plasma (PRP).
Aim: This study was conducted to evaluate the role of PRP in the fast healing of wounds and complications in oral surgical procedures.
Article Synopsis
- - The study evaluated the effectiveness of immediate implant placement in tooth extraction sockets, comparing outcomes with and without platelet-rich fibrin (PRF).
- - Forty extraction sites were randomly divided into two groups: one receiving implants with PRF and the other without it, with radiographic assessments made at the time of placement and after one year.
- - Results indicated that implants placed with PRF showed better preservation of crestal bone levels after 12 months compared to those without PRF.
Background: Virtual surgical planning (VSG), also known as computer-assisted reconstruction, has started to become the norm for more complex patients in many centers in recent times.
Aim: This study was conducted to evaluate the VSG in maxillofacial reconstruction surgery.
Methods And Materials: This study included 20 patients who underwent surgery for maxillofacial reconstruction.
Background: Antimicrobial endodontic intracanal medicaments play a vital role along with biomechanical preparation in the elimination of bacteria present in the pulp area to achieve success in endodontic therapy.
Aim: The present research was conducted with the objective of evaluating and comparing intracanal medicaments regarding antibacterial properties against .
Materials And Methods: One hundred and twenty healthy human premolars of the mandible were used.
Background: Currently, one of the most prevalent oral abnormalities is malocclusion. There is a rising percentage of patients who are willing to undertake orthodontic procedures.
Aim: To evaluate the impact of orthodontic treatment on the morphology of temporomandibular joint (TMJ) in patients with malocclusion associated with TMJ abnormality such as skeletal class II deep bite malocclusion using CBCT.
Article Synopsis
- Genomic methylation shows promise as a tool for identifying oral potentially malignant disorders (OPMDS) and oral cancer, which could enhance understanding of cancer mechanisms and lead to new therapies.
- A study involving 112 patients with premalignant and malignant oral lesions analyzed saliva samples to investigate genetic markers like p16, DAP-K, and MGMT using advanced DNA methylation technology.
- Findings indicated that 12.7% of oral cancer lesions displayed methylation of the examined genes, with higher rates of co-methylation, suggesting these genetic markers can aid in predicting the progression of oral cancer and patient outcomes.
Article Synopsis
- The study investigates the unexplained causes of oral lichen planus (OLP), which is linked to an immune response involving T-cells, by examining the role of oral microorganisms.
- Researchers analyzed 82 tissue samples from OLP patients and 20 from healthy individuals using immunohistochemistry to identify specific microorganisms.
- The findings revealed that various microorganisms, including certain periodontopathogenic bacteria and human papillomavirus types 16 and 18, were more frequently present in OLP patients than in healthy controls, suggesting a potential connection to the condition's development.
Background And Aim: Tissue repair surrounding implants is essential for the cosmetic maxillary anterior zone to respond favorably to implant therapy. Grafting platelets from an individual's blood was developed to overcome the esthetic requirements and speed up healing. Advanced platelet-rich fibrin (APRF) and concentrated growth factor (CGF) are used for good healing.
View Article and Find Full Text PDFArticle Synopsis
- Genetic polymorphisms significantly impact human health, particularly in the context of diseases like oral submucous fibrosis (OSMF), a condition that can lead to cancer.
- This study examined variations in cancer-metabolizing genes (CYP1A1 and GSTM1) in patients with OSMF, comparing genetic markers in patients with different stages of the condition and a control group.
- Results indicated higher prevalence of specific gene polymorphisms in patients with OSMF and especially those with cancer, highlighting the crucial influence of these genetic variations on disease progression.
Background: Minimal intrusive TMJ operations have been recommended as a substitute for conservative therapy when conservative measures fail to relieve significant acute pain, chronic discomfort, inflammation, and/or degenerative illness, specifically in TMD cases.
Aim: This study was conducted to investigate minimally invasive approaches (TMJ arthrocentesis and TMJ arthroscopy) in the treatment of temporomandibular joint (TMJ) disorders.
Methods And Materials: It was a prospective study which included 30 clinically and radiographically diagnosed cases of TMDs.
Background: Applying automated laser ablation procedures with pulsed, electronically administered diode laser equipment, and large-area masking results in highly aligned, uniform microstructures on these surfaces.
Aim: Clinical evaluation of role of laser in soft tissue surgical guide for implant placement.
Methods And Materials: This study included 30 patients with dental implants in their oral cavity.
Background: One emerging and important research method for biomechanical assessments in biological investigations is the finite element analysis (FEA). It is the best technique for simulating intricate structures and examining their mechanical characteristics.
Aim: This study was conducted to compare the V-shaped design and square thread design regarding their influence on the stress and strain distribution using the finite element method.
The salivary concentrations of alpha L fucosidase (AFU) and salic acid (SA) in oral submucous fibrosis patients and compare it with healthy controls is of interest to dentists. 40 patients of OSMF and 40 healthy controls were included. Estimation of AFU and SA in saliva and serum was carried out in every patient.
View Article and Find Full Text PDFHerbal remedies have demonstrated remarkable effects as anti-diabetic, anticancer, antimicrobials, immunological modulatory agent in liver problems, respiratory illnesses, and as beauty agents. The need for more affordable, readily accessible, and alternative medicines has led to a rise in the recognition of herbal drugs. Therefore, it is of interest to evaluate and compare the effectiveness of photosensitized curcumin fibers, Aloevera, Amla Juice and Pancha Tulsi in disinfecting guttapercha (GP) cones.
View Article and Find Full Text PDFLight Amplified Stimulated Emission of Radiation (LASER) is nowadays widely studied regarding their use in endodontics and restorative dentistry. Therefore, it is of interest to evaluate the antibacterial activity of three types of LASERs namely CO2 LASER.Er, Cr:YSGG LASER and Diode LASER in disinfection of root canals.
View Article and Find Full Text PDFImmuno-histochemical evaluation of CD34 in oral lichen planus (OLP) and Oral Submucous Fibrosis (OSMF) is of interest to dentist.20 specimens of normal oral mucosa (buccal mucosa/gingiva tissue) from patients who had extractions performed as part of orthodontic treatment comprised Group I, the control group. Group II comprised 30 individuals with a diagnosis of oral lichen planus.
View Article and Find Full Text PDFBackground: Achieving an optimal shade match for these restorations is crucial for aesthetic outcomes. The thickness of zirconia/glass veneer and the choice of implant abutment material play vital roles in determining the final shade of implant restorations.
Materials And Methods: This study investigated the influence of zirconia/glass veneer thickness (0.
Objective: Oral squamous cell carcinoma (OSCC) is a prevalent malignancy with a significant impact on global health. The identification of non-invasive biomarkers for early detection and monitoring of OSCC remains crucial.
Methods: A total of 100 subjects, comprising 50 patients with histopathologically confirmed OSCC and 50 age- and sex-matched healthy controls, were enrolled in the study.
Unlabelled: This study addresses the durability and complications of zirconia dental implants through a prospective clinical investigation. Zirconia implants are increasingly utilized in dental implantation, and a comprehensive understanding of their long-term performance is essential.
Background: Zirconia dental implants have gained attention due to their biocompatibility and aesthetics.