Convolutional neural networks for accurate real-time diagnosis of oral epithelial dysplasia and oral squamous cell carcinoma using high-resolution in vivo confocal microscopy.

Oral cancer detection is based on biopsy histopathology, however with digital microscopy imaging technology there is real potential for rapid multi-site imaging and simultaneous diagnostic analysis. Fifty-nine patients with oral mucosal abnormalities were imaged in vivo with a confocal laser endomicroscope using the contrast agents acriflavine and fluorescein for the detection of oral epithelial dysplasia and oral cancer. To analyse the 9168 images frames obtained, three tandem applied pre-trained Inception-V3 convolutional neural network (CNN) models were developed using transfer learning in the PyTorch framework.

Gift of Vision - Doorstep-to-Doorstep Outreach Eye Care Model, Sankara Model of Accessible and Affordable Eye Care, and its Impact on the Elderly.

Vision loss among the elderly is a major health-care problem. Vision impairment is associated with a decreased ability to perform activities of daily living and an increased risk for depression. Cataract is a common cause of vision impairment among the elderly, but surgery is often effective in restoring vision.

Assessing bias in the causal role of HPV in oral cancer: A systematic review and meta-analysis.

Objective: High-risk human papillomaviruses (HPV) are an established cause of oropharyngeal cancer. Their relationship with oral cancer remains unclear with detection ranging from 0% to 100%. HPV DNA detection or evidence of exposure alone is insufficient to conclude causality.

Internet of Things enabled open source assisted real-time blood glucose monitoring framework.

Regular monitoring of blood glucose levels is essential for the management of diabetes and the development of appropriate treatment protocols. The conventional blood glucose (BG) testing have an intrusive technique to prick the finger and it can be uncomfortable when it is a regular practice. Intrusive procedures, such as fingerstick testing has negatively influencing patient adherence.

Crystal structure of the tegument protein UL82 (pp71) from human cytomegalovirus.

Human cytomegalovirus (HCMV) is an opportunistic pathogen that infects a majority of the world population. It may cause severe disease in immunocompromised people and lead to pregnancy loss or grave disabilities of the fetus upon congenital infection. For effective replication and lifelong persistence in its host, HCMV relies on diverse functions of its tegument protein UL82, also known as pp71.

Acquisition and annotation in high resolution digital biopsy by confocal microscopy for diagnosis in oral precancer and cancer.

Introduction: Scanned fibre endomicroscopes are full point-scanning confocal microscopes with submicron lateral resolution with an optical slice thickness thin enough to isolate individual cell layers, allow active positioning of the optical slice in the z-axis and collection of megapixel images. Here we present descriptive findings and a brief atlas of an acquisition and annotation protocol high resolution capture of oral mucosal pathology including oral squamous cell carcinoma and dysplasia using a fluorescence scanned fibre endomicroscope with 3 topical fluorescent imaging agents: fluorescein, acriflavine and PARPi-FL.

Methods: Digital biopsy was successfully performed an acquisition protocol in seventy-one patients presenting for investigation of oral mucosal abnormalities using a miniaturized, handheld scanned fibre endoscope.

Granulomatous cheilitis of Miescher: a rare entity.

Background: Granulomatous cheilitis (GC) is a rare entity of unknown etiology. It is a chronic inflammatory disorder with a predilection for young females. It is characterized by asymptomatic unrelenting swelling of lips.

Association between nurses' perceived self-confidence in performing family witnessed resuscitation and implementation of the practice at Siaya County Referral Hospital in Kenya.

Objectives: This study aimed to identify the relationship between nurses' perceived self-confidence in performing family-witnessed resuscitation and the implementation of the practice among nurses and to describe nurses' preferences regarding family-witnessed resuscitation practice.

Methods: This study was a cross-sectional survey. A stratified random sampling design was used to obtain study participants from various units within the medical-surgical departments of the hospital.

Influence of dodecyl surfactants on the cross-linking, plasticization and damping behavior of epoxy novolac resins.

A series of modified epoxy novolac resins (ENRs) were prepared by incorporating dodecyl chain surfactants with polar groups such as amine, carboxylic acid, phenol, resorcinol and benzene sulfonic acid. Except for the case of benzene sulfonic acid, no macrophase separation is seen in any of the modified ENRs. The addition of these dodecyl surfactants to ENR hinders the cross-linking reaction as revealed from their dynamic and isothermal DSC curing measurements and reduced glass transition temperatures ().

Extreme purifying selection against point mutations in the human genome.

Large-scale genome sequencing has enabled the measurement of strong purifying selection in protein-coding genes. Here we describe a new method, called ExtRaINSIGHT, for measuring such selection in noncoding as well as coding regions of the human genome. ExtRaINSIGHT estimates the prevalence of "ultraselection" by the fractional depletion of rare single-nucleotide variants, after controlling for variation in mutation rates.

Confocal microscopy in oral cancer and oral potentially malignant disorders: A systematic review.

Objective: To systematically identify and summarise current research on the utility of confocal microscopy in oral squamous cell carcinoma and oral epithelial dysplasia in oral potentially malignant disorders.

Methods: Databases Medline, Embase, Evidence-Based Medicine, and Web of Science were searched with articles screened and included if their primary objective was the use of a confocal microscope in diagnosis of oral cancer or epithelial dysplasia, in vivo or ex vivo.

Results And Discussion: Twenty-eight relevant studies were identified of which 21 studies included oral squamous cell carcinoma specimens.

Automated image quality appraisal through partial least squares discriminant analysis.

Purpose: Automatic retinal fundus image quality analysis is one of the most essential preliminary stages in automatic computer-aided retinal disease diagnosis system, which allows good-quality fundus images for accurate disease prediction through localization and segmentation of retinal regions. This paper presents new feature extraction methods using full-reference and no-reference image quality metrics for image quality classification.

Methods: Basic image features, reference and no-reference features are extracted from the fundus image and applied through different classification techniques to determine the image quality for further diagnosis.

Spinal Dysraphisms: A New Anatomical-Clinicoradiological Classification.

 Spinal dysraphisms refer to the congenital abnormalities of the spine and spinal cord due to aberrations in the processes of gastrulation, primary neurulation, and secondary neurulation. Embryology of many complex spinal dysraphisms are yet poorly understood and there is no agreeable anatomical-clinicoradiological classification with inclusion of recently documented and complex spinal dysraphisms.  The main objective of this study was to review the imaging features of spinal dysraphisms with a better understanding of embryological abnormalities and propose a new classification inclusive of all complex and unusual dysraphisms based on anatomical and clinicoradiological correlation.

A Systematic Review of MicroRNA Signatures Associated with the Progression of Leukoplakia with and without Epithelial Dysplasia.

Oral cancer is a significant public health issue, being the eighth most common cancer worldwide with over 300,000 cases diagnosed annually. Early diagnosis and adequate management of oral potentially malignant disorders (OPMDs) before transformation into oral squamous cell carcinoma (OSCC) is critical to reduce deaths, morbidity, and to improve overall prognosis. MicroRNAs (miRNAs) are small noncoding RNAs involved in the post-transcriptional regulation of protein expression and implicated in the control of numerous cellular pathways and impacting physiological, developmental, and pathological processes.

Remote monitoring for heart failure: Assessing the risks of readmission and mortality.

Study Objective: Remote monitoring (RM) can help patients with heart failure (HF) remain free of hospitalization. Our objective was to implement a patient-centered RM program that ensured timely clinical response, which would be associated with reduced mortality.

Design: This was a retrospective, observational, propensity-matched study.

Efficacy of Blended Collaborative Care for Patients With Heart Failure and Comorbid Depression: A Randomized Clinical Trial.

Importance: Depression is often comorbid in patients with heart failure (HF) and is associated with worse clinical outcomes. However, depression generally goes unrecognized and untreated in this population.

Objective: To determine whether a blended collaborative care program for treating both HF and depression can improve clinical outcomes more than collaborative care for HF only and physicians' usual care (UC).

CACO-2 cells: A continuous cell line with sensitive and broad-spectrum utility for respiratory virus culture.

Background: Primary rhesus monkey kidney cells (RhMK) can be used for the detection of respiratory viruses, including influenza and parainfluenza. The human colon adeno-carcinoma cell line, CACO-2, has been previously used for the growth of multiple influenza viruses, including seasonal, novel and avian lineages.

Objective: We compared CACO-2, Madin-Darby Canine Kidney (MDCK), and RhMK cells for the isolation of viruses from patients presenting with influenza like-illness (ILI).

Adhesion of Denture Characterizing Composites to Heat-Cured, CAD/CAM and 3D Printed Denture Base Resins.

Purpose: To measure the adhesion of the denture characterizing composite to heat-cured, CAD/CAM and 3D printed denture base resins.

Methods And Materials: Two different denture characterizing composites with different viscosities (SR Nexco; high viscosity (SR) and Kulzer Cre-active; low viscosity (K)) and three denture base resins (Heat cure, CAD-milled and 3D printed) were investigated. 60 beams (25 × 4 × 3 mm) were fabricated for each denture base resin; 30 were bonded to SR and 30 to K to form a beam 50 × 4 × 3 mm.

Patient satisfaction with esthetics, phonetics, and function following implant-supported fixed restorative treatment in the esthetic zone: A systematic review.

Objective: To determine patient satisfaction with esthetics, phonetics, and function following implant-supported fixed restorative treatment in the esthetic zone by measuring the Oral Health Related Quality of Life (OHRQoL).

Materials And Methods: This systematic review follows the "Preferred reporting items for systematic review and meta-analysis protocols" (PRISMA-P) 2015 statement. Studies were searched in the databases Ovid, PubMed, Web of Science, Scopus, and the Cochrane Library.

Mechanical properties of human oral mucosa tissues are site dependent: A combined biomechanical, histological and ultrastructural approach.

Aim: To investigate load-deformation properties of Thiel-embalmed human oral mucosa tissues and to compare three different anatomical regions in terms of mechanical, histological and ultrastructural characteristic with focus on the extracellular matrix.

Materials And Methods: Thirty specimens from three different regions of the oral cavity: attached gingiva, buccal mucosa and the hard palate were harvested from two Thiel-embalmed cadavers. Mechanical properties were obtained, combining strain evaluation and digital image correlation in a standardised approach.

The Preimplantation Psychosocial Evaluation and Prediction of Clinical Outcomes During Mechanical Circulatory Support: What Information Is Most Prognostic?

Background: Psychosocial evaluations are required for long-term mechanical circulatory support (MCS) candidates, no matter whether MCS will be destination therapy (DT) or a bridge to heart transplantation. Although guidelines specify psychosocial contraindications to MCS, there is no comprehensive examination of which psychosocial evaluation domains are most prognostic for clinical outcomes. We evaluated whether overall psychosocial risk, determined across all psychosocial domains, predicted outcomes, and which specific domains appeared responsible for any effects.