Publications by authors named "Ramana Susarla"
The robustness of the polymer strip film platform to successfully deliver a variety of BCS Class II drug nanoparticles without the need for surfactant while retaining positive characteristics such as nanoparticle redispersibility and fast dissolution is demonstrated. Fenofibrate (FNB), griseofulvin (GF), naproxen (NPX), phenylbutazone (PB), and azodicarbonamide (AZD) were considered as model poorly water-soluble drugs. Their aqueous nanosuspensions, produced via wet stirred media milling, were mixed with hydroxypropyl methylcellulose solution containing glycerin as plasticizer, followed by casting and drying to form films.
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- The study examines the fast drying process of strip-films made with water-soluble, biocompatible polymers to ensure uniform drug distribution and quick dissolution of poorly water-soluble griseofulvin (GF) nano-drug particles.
- Using different drying conditions, the research identified two drying phases: a constant rate period followed by a slower phase, allowing for films to dry in under an hour while keeping GF nanoparticles stable and reducing residual water.
- Results showed that higher viscosity in film precursors led to better drug distribution, maintained GF's crystallinity, and enabled quick drug release in about 20 minutes, proving the potential for improved mechanical properties and drug efficacy.
Noncontact drop-on-demand (DOD) dosing is a promising strategy for manufacturing of personalized dosage units. However, current DOD methods developed for printing chemically and thermally stable, low-viscosity inks are of limited use for pharmaceuticals due to fundamentally different functional requirements. To overcome their deficiency, we developed a novel electrohydrodynamic (EHD) DOD (Appl, Phys, Lett.
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