Shugoshin 1 expression in various cancers: a potential target for therapy.

Shugoshin 1 (SGO1) is one of the Shugoshin (guardian spirit) family proteins, which is reported to be majorly involved in the protection of centromeres and proper segregation of chromosomes during cell division. Recent studies found that the altered expression of SGO1 is associated with various cancers and genetic disorders, and suggested as a target for therapy. In the present study, we have reviewed the available literature on SGO1 gene and protein expression in various cancer-cell lines, animal models and cancer patients, and targeting SGO1 with siRNA/shRNA.

Case-Control Genotyping of the c.788C>T Variant of Transforming Growth Factor-Beta 1 Gene in Otosclerosis in the South Indian Population.

Background: Otosclerosis is a common conductive hearing loss resulting from abnormal bone metabolism. The c.788C>T variant in the transforming growth factor-beta 1 gene is associated with otosclerosis in all studied populations, except the Indian population.

Pharmacogenetic evaluation of 6-mercaptopurine-mediated toxicity in pediatric acute lymphoblastic leukemia patients from a South Indian population.

To evaluate the variants in the genes coding for the proteins involved in thiopurine and folate metabolism with treatment related adverse effects (TRAEs). Eleven variants in seven candidate genes were genotyped in 127 pediatric acute lymphoblastic leukemia patients under 6-mercaptopurine (6-MP) treatment to infer the association of selected genotypes with TRAEs. Among the genotypes inspected, (c.

Giant toxic multinodular goiter with dyspnea: A case report.

Introduction: Toxic multinodular goiter (MNG) involves an enlarged thyroid gland, is a common cause of hyperthyroidism and when it is accompanied by obstructive symptoms such as dyspnea, it carries an indication for surgery.

Case Presentation: We present a case of 47-year old female with multinodular goiter with a rapid increase in size within 2 years. She also reported palpitation, breathlessness on exertion, tachycardia and hand tremor.

Pedigree Analysis and Audiological Investigations of Otosclerosis: An Extended Family Based Study.

Background And Objectives: To analyse the audiometric profile and the pedigree of a large family with otosclerosis to understand the inheritance pattern and its implication in clinical management of the disease. Subjects and.

Methods: Pedigree analysis was performed on the basis of family history and audiometric tests.

Detection of high frequency of mutations in a breast and/or ovarian cancer cohort: implications of embracing a multi-gene panel in molecular diagnosis in India.

Breast and/or ovarian cancer (BOC) are among the most frequently diagnosed forms of hereditary cancers and leading cause of death in India. This emphasizes on the need for a cost-effective method for early detection of these cancers. We sequenced 141 unrelated patients and families with BOC using the TruSight Cancer panel, which includes 13 genes strongly associated with risk of inherited BOC.

Minor's Test: Objective Demonstration of Horner's Syndrome.

To highlight the Minor's test, which is useful in demonstrating anhidrosis of Horner's syndrome. A 39 year old female presented to us with a slow growing neck swelling which was provisionally diagnosed as a probable case of cervical sympathetic chain (CSC) Schwannoma. Intra operatively, the mass was found arising from the CSC which was sacrificed.

Our Experience with Femoro-Femoral Bypass in the Management of Critical Airway Problems.

The authors present a case report of a 64 year old male patient with thyroid mass and extensive secondaries of the neck and infiltration of the trachea producing severe tracheal stenosis at the level of the thoracic inlet presenting with stridor. Due to the large mass, endotracheal intubation was ruled out; hence a femoro-femoral Cardiopulmonary Bypass was done followed by a median sternotomy, resection of the involved tracheal segment, a total thyroidectomy with neck dissection and finally a tracheal end-to-end anastomosis. The surgery was done in May 2011.

Relationship between intracochlear electrode position and tinnitus in cochlear implantees.

Conclusion: Cochlear implant electrode position has an impact on the rate of tinnitus suppression and generation.

Objective: Suppression of pre-operative tinnitus or a generation of a new tinnitus in cochlear implantees is a known effect of cochlear implantation. The aim of the current study was to evaluate different cochlear implant electrode positions and their relationship with tinnitus suppression and tinnitus generation.

The BRAIN TRIAL: a randomised, placebo controlled trial of a Bradykinin B2 receptor antagonist (Anatibant) in patients with traumatic brain injury.

Background: Cerebral oedema is associated with significant neurological damage in patients with traumatic brain injury. Bradykinin is an inflammatory mediator that may contribute to cerebral oedema by increasing the permeability of the blood-brain barrier. We evaluated the safety and effectiveness of the non-peptide bradykinin B2 receptor antagonist Anatibant in the treatment of patients with traumatic brain injury.

Meningo-encephalocoele of temporal lobe-management by blind SAC closure.

Brain herniation into the middle ear and mastoid is rare but is a described complication of chronic ear disease. The diagnosis is mainly clinical and requires a high index of suspicion. This can be confirmed by imaging studies.

Ectopic thyroid: A rare cause of tracheal obstruction.

The endoluminal presence of thyroid tissue in the trachea is a rare cause of airway obstruction. Only 14 well documented cases of intratracheal ectopic thyroid tissue have been reported in English Literature since 1966. These lesions are mostly benign and nearly all patients present with symptoms of respiratory obstruction.

An unusual complication of intranasal antrostomi.

Intranasal antrostomies are performed for treating maxillary simusitis. Here we present a rare case, who developed maxillary simusitis as a complication of the previous inferior meatal intranasal antrostomy. This case also proves the current concept that even though the inferior meatal antrostomy opening may be patent, the drainage is through the natural ostium.

Role of endoscope and microdebrider in the excision of skull base schwannoma-Arising from the sphenoid sinus.

A 54 year old lady presented with complaint of right sided nasal obstruction for the past 4 years which was persistent and total. Examination revealed a pale mass in the posterior half of the nasal cavity obscuring the choana. It was firm in consistency, pale with a smooth surface.

Papillary thyroid carcinoma in a thyroglossal cyst.

The incidence of Papillary Thyroid Carcinoma in a Thyroglossal Cyst is rare. Only about 160 cases have been reported in the last 85 years. We report a case of Thyroglossal Cyst who underwent Sistrunk ’s Operation.