Publications by authors named "Ramalingam Rajasekaran"

Prevalent worldwide, the Androctonus scorpion genus contributes a vital role in scorpion envenoming. While diverse scorpionisms are observed because of several different species, their secretions to protect themselves have been identified as a potent source of antimicrobial peptide (AMP)-like compounds. Distinctly, the venom of these species contains around 24 different AMPs, with definite molecules studied for their therapeutic potential as antimicrobial, antifungal, antiproliferative and antiangiogenic agents.

View Article and Find Full Text PDF

Introduction: Pseudogenes have been implicated for their role in regulating cellular differentiation and organismal development. However, their role in promoting cancer-associated differentiation has not been well-studied. This study explores the tumour landscape of oesophageal carcinoma to identify pseudogenes that may regulate events of differentiation to promote oncogenic transformation.

View Article and Find Full Text PDF

BCL11A-XL directly binds and represses the fetal globin (HBG1/2) gene promoters, using 3 zinc-finger domains (ZnF4, ZnF5, and ZnF6), and is a potential target for β-hemoglobinopathy treatments. Disrupting BCL11A-XL results in derepression of fetal globin and high HbF, but also affects hematopoietic stem and progenitor cell (HSPC) engraftment and erythroid maturation. Intriguingly, neurodevelopmental patients with ZnF domain mutations have elevated HbF with normal hematological parameters.

View Article and Find Full Text PDF

The KRAS G12D mutation is very frequent in many cancers, such as pancreatic, colon and lung, and has remained undruggable for the past three decades, due to its smooth surface and lack of suitable pockets. Recent small pieces of evidence suggest that targeting the switch I/II of KRAS G12D mutant could be an efficient strategy. Therefore, in the present study, we targeted the switch I (residues 25-40) and switch II (residues 57-76) regions of KRAS G12D with dietary bioflavonoids in comparison with the reference KRAS SI/II inhibitor BI-2852.

View Article and Find Full Text PDF

Huntington's disease (HD) is a distressing, innate neurodegenerative disease that descends from CAG repeat expansion in the huntingtin gene causing behavioral changes, motor dysfunction, and dementia in children and adults. Mutation in huntingtin (HTT) protein has been suggested to cause neuron loss in the cortex and striatum through various mechanisms, including abnormal regulation of transcription, proteasomal dysfunction, posttranslational modification, and other events regulating toxicity. Pathogenesis of HD involves cleavage of the huntingtin protein followed by the neuronal accumulation of its aggregated form.

View Article and Find Full Text PDF

Multi-drug resistance is a major issue faced by the global pharmaceutical industry. Short antimicrobial peptides such as anoplins can be used to replace antibiotics, thus mitigating this issue. Antimicrobial activity, non-toxicity, and structural stability are essential features of a therapeutic drug.

View Article and Find Full Text PDF

A new series of bio active Cu(II) and Zn(II) complexes [CuL(phen)](OOCCH) (), [ZnL(phen)](OOCCH) (), [CuL(bpy)](OOCCH) (), [ZnL(bpy)](OOCCH) () have been synthesized using the pyrimidine derivative Schiff base () [ = 2-(4,6-dimethylpyrimidin-2-ylimino)methyl)-4-nitrophenol], 1,10-phenanthroline (phen), 2,2'-bipyridine (bpy) and acetate salts of Cu(II) and Zn(II). UV-Visible, FT-IR, H-NMR, ESR, elemental analysis, molar conductance and EI-MS spectral techniques have been used to endorse the square planar geometry for the complexes -. The optimized molecular structure and the harmonic vibrational frequencies have been scrutinized by DFT methods.

View Article and Find Full Text PDF

In this article, we have reported the preparation and structural characterization of a new Schiff base ligand (E)-2-(((2,6-difluorophenyl)imino)methyl)phenol (HSBL) and its derived metal(II) complexes [Cu(SBL)] (1), [Ni(SBL)] (2) and [Pd(SBL)] (3). Using various analytical and spectroscopic techniques, their structural properties have been appraised. The proposed chemical structure of HSBL has been confirmed by Single crystal XRD studies.

View Article and Find Full Text PDF

Increasing death rates due to antibiotic resistance deteriorate the existing treatment measures. Antimicrobial peptides have turned into the emerging cure for multidrug resistance. However, the stability and functionality determine an antimicrobial peptide as a drug.

View Article and Find Full Text PDF

Biochemically active Cu(II) and Zn(II) complexes [CuL(ClO)(1) and ZnL(ClO)(2)] have been synthesized from N,N donor Schiff base ligand L derived from4,6-dichloropyrimdine-5-carboxaldehyde with 4-(2-aminoethyl)morpholine. The L, complexes 1 and 2 have been structurally characterized by elemental analysis, H-NMR, FTIR, MS, UV-Visible and ESR techniques. The results obtained from the spectral studies supports the complexes 1 and 2 are coordinated with L through square planar geometry.

View Article and Find Full Text PDF

Computational methods have refined the mode of peptide drug designing to a new plateau recently. Circulin, a 30 residue natural plant polypeptide acts as a plant defensive peptide. Additional to its antimicrobial activity it also possesses an inhibitory cytopathic effect on the replication of human immunodeficiency virus (HIV).

View Article and Find Full Text PDF
Article Synopsis
  • * Molecular dynamics (MD) simulations revealed that both mutations caused significant changes in the protein's backbone dynamics, leading to structural distortions in specific α-helix regions, ultimately disrupting hydrogen bonds and local protein folding.
  • * Principal component analysis showed these mutants experienced differing conformational dynamics, making them structurally disordered and unable to perform the same functions as the wild type ADD domain, offering insights into how these mutations affect ATRX syndrome at a molecular level.
View Article and Find Full Text PDF
Article Synopsis
  • A missense mutation (L270P) in the Wiskott-Aldrich syndrome protein (WASP) leads to its constant activation, contributing to the development of X-linked neutropenia (XLN).
  • Using all atom molecular dynamics (MD) simulations, researchers studied the structural changes in the mutated WASP, observing increased flexibility and reduced intra-molecular hydrogen bonding.
  • The decreased hydrogen bonds impair the protein's local folding, causing it to adopt a more unfolded state that enhances bonding with Cdc42, its interacting partner, due to increased conformational variability.
View Article and Find Full Text PDF

A PHP Error was encountered

Severity: Warning

Message: fopen(/var/lib/php/sessions/ci_sessionfclrle1vdbrlec7fihp1tt2um7vbflv7): Failed to open stream: No space left on device

Filename: drivers/Session_files_driver.php

Line Number: 177

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: session_start(): Failed to read session data: user (path: /var/lib/php/sessions)

Filename: Session/Session.php

Line Number: 137

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once