Clonostachys rosea, a marine algal endophyte, as an alternative source of chrysin and its anticancer effect.

Endophytic fungi were isolated from the marine green alga Chaetomorpha antennina and identified as Clonostachys rosea through molecular analysis. C. rosea was grown in a tryptophan medium for 21 days and after that, the metabolites were extracted by ethyl acetate.

Retracted: Isolation and purifications of an ambuic acid derivative compound from marine algal endophytic fungi Talaromyces flavus that induces apoptosis in MDA-MB-231 cancer cells.

In recent years, there has been a lot of buzz about the possibilities of marine microflora as a source of new therapeutic drugs. The strong anti-tumor potency of compounds found in marine resources reflects the ocean's enormous potential as a source of anticancer therapeutics. In this present investigation, an ambuic acid derivative anticancer compound was isolated from Talaromyces flavus, and its cytotoxicity and apoptosis induction potential were analyzed.

Curative Potential of High-Value Phytochemicals on COVID-19 Infection.

Medicinal plants and their therapeutically promising chemical compounds belonging to the valued category of 'traditional medicine' are potential remedies for various health problems. Due to their complex structure and enormous health benefits, the high-value plant-derived metabolites collectively termed as 'phytochemicals' have emerged as a crucial source for novel drug discovery and development. Indeed, several medicinal plants from diverse habitats are still in the 'underexplored' category in terms of their bioactive principles and therapeutic potential.

Antidiabetic potential of Gymnemic acid mediated gold nanoparticles (Gym@AuNPs) on Streptozotocin-induced diabetic rats-An implication on in vivo approach.

Gymnemic acid is glycosides of triterpene with recognized and valuable applications for several chronic diseases, mainly diabetics. Despite this, it requires a delivery system in order to range its therapeutic target due to its limited solubility and bioavailability. Therefore, the Gymnemic acid mediated gold nanoparticles (Gym@AuNPs) was synthesised by eco-friendly approach.

Synthesis of Nickel-Chitosan Nanoparticles for Controlling Blast Diseases in Asian Rice.

Rice blast caused by Pyricularia oryzae is one of most devastating fungal diseases in rice, reducing the annual yield of rice worldwide. As an alternative to fungicide for curbing rice blast, synthesis of nickel-chitosan nanoparticles (Ni-Ch NPs) was performed with nickel chloride and assessed its efficacy in inflating plant growth and hindrance of Pyricularia oryzae (blast pathogen). Characterization of Ni-Ch NPs from SEM, TEM, and DLS analyses showed smooth- and spherical-shaped nanoparticles in the range of 20-70 nm.

Synthesis of β-Glucan Nanoparticles from Red Algae-Derived β-Glucan for Potential Biomedical Applications.

The present study highlights/demonstrates facile synthesis of β-Glucan nanoparticles (β-GluNPs) that can be used in the prevention of breast cancer and other infectious diseases. Moreover, this method is inexpensive and shows effectivity towards different biological applications. Further, the characterization of synthesized β-GluNPs was exclusively confirmed through UV-Vis spectroscopy, Fourier transform infrared spectroscopy (FT-IR), dynamic light scattering (DLS), zeta potential, scanning electron microscopy (SEM), high resolution-transmission electron microscopy (HR-TEM), and X-ray powder diffraction (XRD) analysis.

Vinblastine production by the endophytic fungus Curvularia verruculosa from the leaves of Catharanthus roseus and its in vitro cytotoxicity against HeLa cell line.

The current study was to isolate endophytic fungi producing high yields of indole alkaloids such as vinblastine analogous to their host Cathranthus roseus. Endophytic fungi were isolated from the leaves of C. roseus, identified as Curvularia verruculosa by molecular techniques, and the sequence was deposited in NCBI (MK995628).

Withanolide production by fungal endophyte isolated from Withania somnifera.

Withanolides, the secondary metabolite from Withania species is used in Ayurvedic medicine and now proved to have potential use in treating cardiovascular, Alzheimer's disease, etc. Its production in plants varies between genotypes with very low yield. For improved industrial commercialisation, there is a need to increase its production.

Lovastatin-producing endophytic fungus isolated from a medicinal plant Solanum xanthocarpum.

Lovastatin is a potent drug for lowering blood cholesterol. An endophytic fungus Phomopsis vexans was isolated from the healthy leaf tissues of Solanum xanthocarpum, a medicinal plant, and screened for lovastatin production. The fungus was identified by their characteristic cultural morphology and molecular analysis.

Gymnemagenin-producing endophytic fungus isolated from a medicinal plant Gymnema sylvestre R.Br.

Gymnema sylvestre is a plant containing the triterpenoid gymnemagenin, which is used in the pharmaceutical industry as an antidiabetic agent. The objective of this study was to determine whether endophytic fungi, isolated from G. sylvestre, produce gymnemagenin.