Publications by authors named "Ramalingam K"

Odor emissions, primarily from anthropogenic activities like waste treatment and industrial processes, pose significant challenges in urban areas, particularly near water resource recovery facilities. While these emissions are generally not toxic, they can adversely affect community wellbeing and investment, prompting stricter regulations in some regions. For example, New York State's hydrogen sulfide guidelines are more stringent than federal standards.

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Importance: Intratumoral immunotherapy that leverages the biological characteristics of high-risk ductal carcinoma in situ (DCIS) may be able to reduce the extent of surgical treatment and provide an alternative approach to improve patient outcomes.

Objective: To determine if combination intratumoral immunotherapy can activate immune cells to shrink or eliminate high-risk DCIS.

Design, Setting, And Participants: This phase 1 open-label nonrandomized clinical trial at a single academic center tested the safety and efficacy of intratumoral immunotherapy in patients with high-risk DCIS, defined as at least 2 of the following present: younger than 45 years, tumor size greater than 5 cm, high-grade, palpable mass, hormone receptor (HR)-negative, or ERBB2-positive.

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Soil degradation due to industrialization is a growing global concern, emphasizing the importance of evaluating soil quality near industrial zones to ensure food security, environmental sustainability, and public health. This study compares soil quality across five industrial sites, including foundries, electroplating, paper mills, textile mills, and quarries and cement industries, in the Coimbatore district. Soil samples were collected via a purposive sampling approach from nearby agricultural fields via a 500 m grid.

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This study addresses the critical challenges faced by global aquatic industries such as overfishing, habitat destruction, pollution, climate change, and unsustainable aquaculture practices. It focuses on developing effective solutions by synthesizing potent inhibitors against Vibrio parahaemolyticus of two strains namely: MTCC-451 (A) and Vp-S14 (B). Biginelli's compounds (B1-4) were identified as promising inhibitors with confirmed antibacterial activity through in silico and in vitro studies.

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Article Synopsis
  • Oral verruciform xanthoma (OVX) is a rare, benign oral lesion that can resemble other common growths and has only a few documented cases.
  • It typically appears in areas like the masticatory mucosa, with its exact cause still uncertain, but it's thought to arise from monocyte/macrophage lineage.
  • In a reported case, a 20-year-old male had a keratotic growth on his lower lip that was diagnosed as OVX through histopathology and immunohistochemistry; it was successfully surgically excised with no recurrence afterward.
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  • Dental surgeons can enhance patient awareness of oral hygiene by using plaque-disclosing solutions and teaching proper brushing techniques.
  • The study showed that these methods significantly improve self-performed dental plaque control, which is crucial as plaque contributes to many oral diseases.
  • A case report highlighted an adolescent's oral hygiene progress over four weeks, with a noticeable reduction in plaque and gingival index scores after implementing the techniques.
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Traumatic ulcerative granuloma with stromal eosinophilia (TUGSE) is a rare, benign lesion often misdiagnosed due to its clinical and histological similarities with malignant conditions. It typically presents as a persistent, non-healing ulcer in the oral cavity. This case report describes a 64-year-old female patient who presented with a solitary ulcer caused by chronic trauma from a supra-erupted tooth.

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This article outlines a systematic workflow for the clinical management of lip swellings, ensuring an accurate diagnosis and appropriate treatment plan. The process involves a thorough clinical examination and necessary diagnostic investigations such as imaging and biopsy, which will guide treatment decisions. Depending on the findings, treatment may range from conservative management to surgical excision.

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Background: In the United States, often only tertiary centers offer cytoreductive surgery and heated intraperitoneal chemotherapy (CRS+HIPEC) for peritoneal metastases in advanced lower gastrointestinal malignancies. Growing evidence shows that Medicaid expansion under the Affordable Care Act (ACA) of 2010 enhanced healthcare access and outcomes.

Objective: We sought to determine whether Medicaid expansion was associated with decreased all-cause mortality of lower gastrointestinal cancer patients following CRS+HIPEC.

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Inflammatory paradental cysts (IPC) are frequently under-reported due to insufficient clinical details. Our case report describes a 45-year-old male with a complaint of discomfort in the right lower posterior region. Intra-oral examination revealed a partially erupted, mesioangularly impacted 48 without any dental caries.

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Trabecular juvenile ossifying fibroma (TrJOF) is a rare, benign, fibro-osseous lesion that predominantly affects children and adolescents. The lesion is locally aggressive, has a high recurrence rate, and is often misdiagnosed due to its clinical and radiographic similarities to other lesions. A seven-year-old female presented with a history of swelling and pain on the right side of her face for the last month.

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Sebaceous hyperplasia is a benign condition characterized by an overgrowth of sebaceous glands, often presenting as small, soft, yellowish papules on areas rich in sebaceous glands, such as the face. While the condition is harmless, it can mimic other dermatological conditions, such as basal cell carcinoma. This case report describes a 71-year-old female with sebaceous hyperplasia presenting as wart-like lesions and whiteheads on the forehead and cheek regions.

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Background Internal audits are essential tools for enhancing the operational efficiency, quality, and effectiveness of healthcare departments. Audits enable the departments and laboratories to meet the changing needs of the healthcare environment by giving a detailed picture of the department's operations and highlighting areas for possible growth and development. Aims and objectives This study focuses on the biopsies received in the Oral Pathology Department at Saveetha Dental College, aiming to evaluate biopsy trends, financial performance, and resource utilization over one year.

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We report a case of mucocele of the lower lip in a 17-year-old female patient. She complained of a painless swelling on her lower lip for the last one month. The patient also gave a history of lip-biting.

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  • Oral squamous cell carcinoma (OSCC) poses significant challenges for clinicians and pathologists, as illustrated by a unique case involving the left buccal mucosa that included severe bone exposure and skin perforation.
  • The case exhibited alarming symptoms such as ulceration, necrosis, and maggot infestation, with histological analysis revealing poorly differentiated malignant cells that indicated a severe form of the disease.
  • The report highlights the critical importance of early diagnosis and treatment to halt disease progression, mitigate immune suppression, and enhance patient quality of life.
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  • Oral lichen planus (OLP) is a chronic inflammatory condition affecting the oral mucosa, which can severely impact patients' quality of life due to discomfort and anxiety.
  • A study at Saveetha Dental College analyzed the anxiety and depression levels of 212 OLP patients, with their data collected over one year, including factors like age, gender, and associated medical conditions.
  • The study found that the most affected age group was 51-60 years, predominantly female, with many reporting burning sensations as the main symptom, and a small percentage having comorbidities like Grinspan syndrome.
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  • - Oral plexiform neurofibromas are benign tumors of peripheral nerves characterized by a "plexus" or "bag of worms" appearance and have higher chances of recurring and potentially becoming malignant.
  • - A case study involves a young male with this type of tumor in the buccal mucosa, who was recommended to undergo a full-body exam to check for neurofibromatosis.
  • - Although surgery is the typical treatment, understanding the mechanisms behind recurrences is important for better surgical success and management, especially since involved anatomical structures can limit the extent of removal.
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Background Gram-negative is a common bacteria that is well-known for its capacity to build biofilms, which are organized cell communities encased in a self-produced polymeric matrix. Treating infections becomes more challenging due to biofilms' capacity to provide immunity and resistance to antibiotics. The search for novel anti-biofilm agents has gained significant momentum, and the diverse range of bioactive compounds found in natural products offers a promising avenue.

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  • Trigeminal neuralgia (TN) is a painful disorder affecting the trigeminal nerve, causing severe facial pain and often requiring treatments like medications or surgical procedures when drugs are ineffective.
  • This study analyzed 483 TN cases over five years to understand patient demographics, focusing on age, gender, and which divisions of the trigeminal nerve were most affected.
  • Results showed that the average patient age was around 60 years, with the majority experiencing pain on the right side of the face, primarily affecting the maxillary (V2) and mandibular (V3) nerve divisions.
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  • Cone-beam computed tomography (CBCT) is a useful imaging method for diagnosing dental issues and understanding the link between maxillary sinuses and dental roots, emphasizing the need for careful assessment of incidental findings.
  • A study analyzed CBCT scans from 300 individuals between 18 to 70 years old to evaluate the prevalence of incidental maxillary sinus pathologies and their connection to dental diseases.
  • Findings revealed that 52.05% of subjects had incidental maxillary sinus findings, with a higher occurrence in males and those aged 46 to 55, showing various associations between sinus issues and dental conditions.
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  • - Osteoblastoma is a rare and benign bone tumor mainly found in the spine but can also appear in the mandible, as seen in a case involving a 38-year-old female with mild pain and swelling.
  • - Diagnosis was confirmed through clinical, radiographic, and histopathological evaluations, leading to a conservative surgical excision with no recurrence during follow-up.
  • - The report highlights the need to differentiate osteoblastoma from similar lesions like low-grade osteosarcoma and osteoid osteoma for proper treatment and better outcomes.
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The most commonly occurring malignant salivary gland tumor is mucoepidermoid carcinoma (MEC). It consists of intermediate cells, squamous cells, and mucous-secreting cells. It is usually not capsulated and is identified by mucocarmine staining.

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Background: Masticatory myofascial pain syndrome (MMPS) is a soft tissue inflammatory disorder that leads to acute or chronic localized pain and stiffness in the muscles. Catechol-O-methyltransferase (COMT) plays a crucial role in mediating pain perceptions in humans by transferring methyl groups to catecholamines. This process requires adequate S-adenosyl methionine (SAMe).

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The progressive overgrowth of the gingiva is the hallmark of idiopathic gingival fibromatosis (IGF). Excess gingival tissue can obscure the crown of a tooth, resulting in spaces between teeth, displacement, retention of primary or permanent teeth, and difficulties with feeding, speaking, and appearance. The diagnosis and management of inherited gingival fibromatosis are the focus of this case report.

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