Publications by authors named "Rama Yarasani"
J Clin Psychopharmacol
June 2023
Article Synopsis
- The study focused on once-daily extended-release (ER) lorazepam, aimed at providing more stable plasma levels for better short-term anxiety relief compared to the immediate-release (IR) version that is taken multiple times a day. !*
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- Three phase 1 studies compared the pharmacokinetics of ER lorazepam with IR, testing factors like food intake and dosage methods, and found that the two formulations were bioequivalent in effectiveness and safety. !*
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- Results showed that ER lorazepam was well tolerated by healthy adults, achieving maximum drug concentration at 11 hours as opposed to 1 hour for IR, suggesting it could be a viable alternative for those using IR lorazepam.
