Publications by authors named "Rama Abdin"
Investigating Efficacy of Atopic Dermatitis Systemic Therapeutics After Discontinuation Part I: Biologics.
J Clin Aesthet Dermatol
February 2025
Objective: The authors sought to review published literature on the efficacy of biologics as monotherapy for atopic dermatitis (AD) following discontinuation.
Methods: A comprehensive search of PubMed/MEDLINE was conducted examining drug withdrawal in AD clinical trials where participants were treated with biologics. Trials were included if they exclusively involved participants with AD that reported the maintenance or achievement of Eczema Area and Severity Index (EASI)-75 and Investigator Global Assessment (IGA) scores of 0 or 1 after withdrawal of biologic therapy.
Acne vulgaris is one of the most common skin diseases worldwide and affects a large population of patients. Post-acne scarring can pose a significant psychosocial burden on patients of all ages; therefore, treatment approaches must be both rapid-acting and effective. Microneedling is a minimally invasive technology that involves the creation of controlled tissue microinjury and subsequent induction of collagen production and tissue remodeling.
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- Acne affects over 90% of adolescents, with about 47% developing acne scars, leading to significant psychological and social impacts, highlighting the need for better treatment options.
- Platelet-rich plasma (PRP) is a treatment derived from the patient's own blood that helps with healing and tissue repair, and may work even better when paired with laser therapy, which creates controlled skin damage to promote regeneration.
- This review analyzed six recent studies and concluded that the combination of PRP and laser therapy results in better outcomes for treating acne scars than using either treatment alone.
Article Synopsis
- Granuloma annulare is a harmless skin condition that isn't caused by an infection, and its exact cause involves complex immune system interactions that are still being studied.
- The primary treatment options are usually steroid creams or injections, but these don't always work well or for a long time in every patient.
- This text discusses a patient with chronic granuloma annulare who was successfully treated with tapinarof cream, a treatment option that hasn't been widely reported before.
Article Synopsis
- Bimekizumab is a new type of antibody that targets two specific proteins (IL-17A and IL-17F) involved in psoriasis, a skin disease.
- It has shown effectiveness in treating moderate-to-severe plaque psoriasis, demonstrating superior results compared to other treatments in both effectiveness and speed.
- In clinical trials, patients experienced significant improvements, with some clearing their psoriasis symptoms within just 72 hours of starting the treatment, marking one of the fastest reported recoveries.
Objective: We sought to review published literature on antibiotic and antiseptic use and resistance, and explore the utility of benzoyl peroxide in this capacity for dermatologic surgery.
Methods: A literature review was performed to investigate the skin microbiome, guidelines on antibiotic and antiseptic use in dermatologic surgery, and the utility of benzoyl peroxide as an antiseptic.
Results: Antiseptics are commonly used in dermatologic surgery to prepare surgical sites, and antibiotics are also employed by some physicians to prevent post-operative infection despite the potential for antibiotic resistance.
Article Synopsis
- Complementary and alternative medicine (CAM) is increasingly being explored in dermatology, especially among skin cancer patients.
- A recent scoping review analyzed studies to quantify the use of biologically based CAM in this population, identifying 6 relevant studies from a pool of 3,150 articles.
- Findings suggest that use of CAM is common and varies based on factors like cancer stage, location, and age, highlighting the need for doctors to have open conversations about CAM to enhance patient care.
Acute myeloid leukemia (AML) is characterized by the rapid proliferation of mutagenic hematopoietic progenitors in the bone marrow. Conventional therapies include chemotherapy and bone marrow stem cell transplantation; however, they are often associated with poor prognosis. Notably, growth hormone-releasing hormone (GHRH) receptor antagonist MIA-602 has been shown to impede the growth of various human cancer cell lines, including AML.
View Article and Find Full Text PDFPlaque psoriasis is a chronic, immune-mediated, cutaneous, and systemic inflammatory dermatosis. Its pathogenesis involves the dysregulation of the interleukin (IL)-23/IL-17 signaling pathway. There are a range of treatment options available, encompassing topical agents, biologics, oral systemic therapy, and phototherapy.
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- Facial hair plays a significant role in men's social and psychological identity, making beard health important.
- This review outlines various causes of beard alopecia, including more common conditions like alopecia areata and pseudofolliculitis barbae, as well as less common ones like dermatopathia pigmentosa reticularis.
- The document serves as a valuable resource for clinicians dealing with patients experiencing beard hair loss.
Treatment of Androgenetic Alopecia: Current Guidance and Unmet Needs.
Clin Cosmet Investig Dermatol
May 2023
Androgenetic alopecia (AGA) is the most common cause of hair loss in men and women. Traditionally, topical minoxidil and oral finasteride have been the standard of care yielding mixed results. New treatments such as Low-Level Laser Therapy (LLLT), microneedling, platelet-rich plasma (PRP), and others have been extensively studied in the literature, and the purpose of this review is to provide a comprehensive discussion of the latest treatment methods and their efficacy in treating AGA.
View Article and Find Full Text PDFTreatment of Androgenetic Alopecia Using PRP to Target Dysregulated Mechanisms and Pathways.
Front Med (Lausanne)
March 2022
Androgenetic alopecia ("AGA") is the most prevalent type of progressive hair loss, causing tremendous psychological and social stress in patients. However, AGA treatment remains limited in scope. The pathogenesis of androgenetic alopecia is not completely understood but is known to involve a hair follicle miniaturization process in which terminal hair is transformed into thinner, softer vellus-like hair.
View Article and Find Full Text PDFThere is growing evidence that the novel coronavirus (SARS-CoV-2) is capable of transmission through the eye. Research suggests that infection by SARS-CoV-2 can produce an inflammation of the conjunctiva, which leads to redness and itchiness of the eyes. Furthermore, viral particles have been detected in conjunctival secretions of SARS-CoV-2 patients who present with conjunctivitis and is likely another mode of transmission.
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