Selector genes display tumor cooperation and inhibition in epithelium in a developmental context-dependent manner.

During animal development, selector genes determine identities of body segments and those of individual organs. Selector genes are also misexpressed in cancers, although their contributions to tumor progression per se remain poorly understood. Using a model of cooperative tumorigenesis, we show that gain of selector genes results in tumor cooperation, but in only select developmental domains of the wing, haltere and eye-antennal imaginal discs of larva.

Synthesis and selectivity in the formation of cyclophosphazene-derived 1,3-cyclohexadienes from reactions of RCpCo(COD) [R = MeOC(O)] with alkynes and alkenes.

The first examples of mono and bisfluorophosphazene derived [eta (5)-cyclopentadienyl] [eta (4)-1,3-cyclohexadiene] cobalt complexes have been prepared along with the sandwich compound [eta (5)-carbomethoxycyclopentadienyl] [eta (4)-1,3-bis(pentafluorocyclotriphosphazenyl)-2,4-diphenylcyclobutadiene] cobalt and acetylene trimerized products from the reactions of [eta (5)-MeOC(O)C 5H 4]Co[COD], PhCCP 3N 3F 5 and phenylacetylene in the presence or absence of an additional cycloalkene or indene. Formation of these mono and bis fluorophosphazene derived cobalt cyclohexadiene complexes provide experimental evidence for a metallacyclopentadiene pathway for cyclohexadiene formation in CpCo catalyzed reactions. Selectivity is also observed in the formation of bisfluorophosphazene derived cyclohexadienes which stems from the fact that two P 3N 3F 5 units cannot be accommodated on vicinal carbon atoms of a carbacycle or metallacycle.