Dithiocarbamate-based novel anti-histaminic agents: synthesis, characterization, crystal structure and thermal study.

A new -(4-fluorobenzyl) -(pyridin-2-ylmethyl) dithiocarbamate ligand () having structural similarity to clinically approved antihistaminic drugs (. pheniramine, chlorpheniramine, and brompheniramine) and its four metal complexes [Co(fbpm)] (1), [Ni(fbpm)] (2), [Cu(fbpm)] (3), and [Zn(fbpm)] (4) were successfully synthesized and characterized by various techniques elemental analysis, FT-IR spectroscopy, HR-MS, NMR spectroscopy, and absorption and emission spectroscopy. Furthermore, complexes 1 and 2 were characterized by single crystal X-ray diffraction.

Co-catalysed synthesis of -(4-meth-oxy-phen-yl)-5-(pyridin-4-yl)-1,3,4-oxa-diazol-2-amine hemi-hydro-chloride monohydrate.

The title compound, CHNO·0.5HCl·HO or H(CHNO) ·Cl·2HO, arose from the unexpected cyclization of isonicotinoyl--phenyl hydrazine carbo-thio-amide catalysed by cobalt(II) acetate. The organic mol-ecule is almost planar and a symmetric N⋯H⋯N hydrogen bond links two of them together, with the H atom lying on a crystallographic twofold axis.

Assembly of New Heterocycles through an Effective Use of Bisaldehydes by Using a Sequential GBB/Ugi Reaction.

A facile route for the assembly of new bis-heterocyclic imidazo[2,1-b][1,3]thiazinyl/benzothiazoyl-phenyl)benzamide scaffolds through a two-step Groebke-Blackburn-Bienaymé (GBB)/Ugi reaction sequence is reported, which establishes multiple points of diversity in the final products. The highlights of this procedure are the survival of the aldehyde group following the GBB reaction without the need for additional protection/deprotection steps. Moreover, the reaction is operationally simple, with the absence of any catalyst, and exhibits excellent functional-group tolerance under minutes of microwave irradiation.