Synopsis of recent research by authors named "Ram Kannan"
- Ram Kannan's recent research focuses on the pathophysiology of age-related macular degeneration (AMD) and breast cancer, exploring underlying mechanisms such as oxidative stress, mitochondrial dysfunction, and cellular senescence in retinal pigment epithelial (RPE) cells.
- Findings indicate that targeting key proteins, such as paraoxonase 2 (PON2) and αB-crystallin, can potentially mitigate oxidative stress-induced retinal damage and offer new therapeutic avenues for advanced breast cancer by readdressing estrogen receptor activity.
- Kannan's studies reveal the persistence of vascular structures post anti-VEGF therapy in choroidal neovascularization, suggesting that mechanisms of vascular regrowth may complicate treatment effectiveness in both animal models and humans.