Context: It is unclear how adolescent glycemic status relates to brain health in adulthood.
Objective: To assess the association between adolescent fasting plasma glucose (FPG) and MRI-based brain measures in midlife.
Design: Between 1973 and 1992, the Bogalusa Heart Study (BHS) collected FPG from children, 3 to 18 years old, and followed up between 1992 and 2018.