Publications by authors named "Ram Ayyar"

Ciguatera Fish Poisoning (CFP) is the most frequently reported seafood-toxin illness in the world. It causes substantial human health, social, and economic impacts. The illness produces a complex array of gastrointestinal, neurological and neuropsychological, and cardiovascular symptoms, which may last days, weeks, or months.

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Ciguatera Fish Poisoning (CFP) is the most frequently reported seafood-toxin illness in the world, and it causes substantial physical and functional impact. It produces a myriad of gastrointestinal, neurologic and/or cardiovascular symptoms which last days to weeks, or even months. Although there are reports of symptom amelioration with some interventions (e.

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Objective: To describe temporal profile of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) in patients with definite, relapsing multiple sclerosis (MS).

Background: Peripheral demyelinating neuropathy has been rarely reported in association with central nervous system demyelinating disorder indistinguishable from MS.

Methods: In addition to usual diagnostic studies for CIDP and MS in all 5 patients, we studied proximal segments of nerves using deep tendon reflex latency measurements of biceps reflex, patellar reflex, and ankle reflex.

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Article Synopsis
  • Small-fiber neuropathy (SFN) is identified through clinical signs and specific small-fiber tests rather than standard nerve conduction studies, which are normal in these cases.
  • This study assessed deep tendon reflex (DTR) latency as a diagnostic tool for SFN by measuring reflexes in 18 SFN patients and 38 control subjects, finding that latencies were significantly longer in SFN patients across all tested reflexes.
  • Results show that DTR latency measurements are reliable and can indicate subclinical large fiber involvement, making it a useful method for diagnosing mild cases of SFN.
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There is a higher incidence of demyelinating peripheral neuropathy responsive to immunomodulating treatment in patients with diabetes mellitus. The diagnosis is often overlooked and the patients are given the label of "diabetic neuropathy." Progressive symmetric or asymmetric motor deficit, progressive sensory neuropathy in spite of optimal diabetic control, and unusually high cerebrospinal fluid protein level in "diabetic neuropathy" should alert the clinician to the possibility of an underlying treatable demyelinating peripheral neuropathy masquerading as "diabetic neuropathy.

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This article addresses the clinical presentations of different peripheral neuropathies. The topic is discussed briefly with emphasis on the most important clinical features. MR imaging of the peripheral nerves is a rapidly advancing field, and it is hoped that the basic understanding of the clinical presentations of peripheral neuropathies will encourage radiologists to get more involved in MR imaging of the peripheral nerves.

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Background: Recent studies have reported that patients with diabetes mellitus (DM) have a predisposition to develop chronic inflammatory demyelinating polyneuropathy (CIDP).

Objectives: To determine whether patients with DM have a polyneuropathy fulfilling electrophysiologic criteria for CIDP, and whether CIDP is more frequent in patients with type 1 than in patients with type 2 DM.

Methods: We prospectively studied the frequency of electrophysiologic changes meeting the criteria for CIDP in patients with DM seen in our electrophysiology laboratory during a 51-month period (period 1).

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Article Synopsis
  • - There is growing evidence that idiopathic chronic inflammatory demyelinating polyneuropathy (CIDP) and diabetes-related polyneuropathy (DM-CIDP) share similarities, prompting a study to see if DM-CIDP responds to IVIG therapy.
  • - In a pilot study with 26 patients with type 2 diabetes, IVIG therapy led to a significant improvement in the Neuropathy Impairment Score in 80.8% of participants after 4 weeks, especially among those with a conduction block.
  • - While the results suggested IVIG therapy may be beneficial for DM-CIDP, the study was uncontrolled, indicating that more research is needed to confirm these findings.
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Background: Case reports exist of femoral neuropathy following renal transplantation (RTSP) with possible pathophysiology, including direct compression and nerve ischemia. However, the occurrence of acute femoral neuropathy (AFN) following RTSP has not been studied prospectively.

Objective: To determine the occurrence of AFN following RTSP.

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Research criteria for the diagnosis of chronic inflammatory demyelinating polyneuropathy (CIDP) were proposed by an Ad Hoc Subcommittee of the American Academy of Neurology (AAN) in 1991, and since then these criteria have been widely used in clinical studies. We have been impressed by the frequent finding of electrophysiological changes of a demyelinating neuropathy in patients whose clinical presentation does not conform to the usually accepted clinical phenotype of CIDP. To determine the clinical spectrum of CIDP, we conducted a retrospective review of patients of the peripheral electrophysiology laboratory of the University of Miami-Jackson Memorial Medical Center.

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