Targeting PD-1 in CD8 T Cells with a Biomimetic Bilirubin-5-fluoro-2-deoxyuridine-Bovine Serum Albumin Nanoconstruct for Effective Chemotherapy against Experimental Lymphoma.

We fabricated bilirubin-bovine serum albumin (BR-BSA) nanocomplexes as candidates for the delivery of 5-fluoro-2-deoxyuridine (5FUdr) against experimental murine lymphoma. BR was attached to 5FUdr via acid-labile ester bonds mimicking small-molecule drug conjugates. The construct was self-assembled with BSA through strong noncovalent interactions with high drug occupancy in the core and labeled with folic acid (FA) to target cancer cells.

Studies on interaction potency model based on drug synergy and therapeutic potential of triple stimuli-responsive delivery of doxorubicin and 5-fluoro-2-deoxyuridine against lymphoma using disulfide-bridged cysteine over mesoporous silica nanoparticles.

A triple stimuli-responsive drug delivery platform involving doxorubicin, 5-fluoro-2-deoxy uridine and folic acid was fabricated on mesoporous silica nanoparticles for targeting delivery against a highly aggressive murine lymphoma called Dalton's lymphoma. Fabrication of the unique construct by amalgamating active and passive targeting mechanisms offers a novel hyper-chimeric platform for a stimuli-responsive drug delivery system. The novel construct enables efficient and precise delivery of the precious cargo to the tumor sites.

Pepsin Assisted Doxorubicin Delivery from Mesoporous Silica Nanoparticles Downsizes Solid Tumor Volume and Enhances Therapeutic Efficacy in Experimental Murine Lymphoma.

Pepsin, a digestive enzyme, plays an important role in the metabolism of protein products in the stomach. The pH is regarded as the most pivotal criteria in appraising the pepsin's enzymatic activity. Pepsin is idle at the physiological pH (7.

Telomerase Responsive Delivery of Doxorubicin from Mesoporous Silica Nanoparticles in Multiple Malignancies: Therapeutic Efficacies against Experimental Aggressive Murine Lymphoma.

Mammalian telomerase maintains the length and integrity of telomeres by adding the telomeric repeats to the chromosome end. This work describes the telomerase responsive delivery of doxorubicin against telomerase positive human and murine cancer cells. Wrapping of doxorubicin loaded mesoporous silica nanoparticles with specific oligonucleotide sequence, containing telomeric repeat complementary sequence and a telomerase substrate primer sequence, resulted in slow and sustained release of doxorubicin, contiguous to the tumor cells.

Donor-π-Acceptor-Type Configured, Dimethylamino-Based Organic Push-Pull Chromophores for Effective Reduction of Mild Steel Corrosion Loss in 1 M HCl.

In this work, donor-π-acceptor-type four crystalline compounds have been tested for the first time to restrict the corrosion of mild steel in 1 M HCl. The details of the compounds are: C1, 4-,-dimethylamino-β-nitrostyrene; C2, 2-(4-(dimethylamino) benzylidene)malononitrile; C3, ethyl 2-cyano-3-(4-(dimethylamino) phenyl)acrylate; and C4, methyl 2-cyano-3-(4-(dimethylamino)phenyl)acrylate. The corrosion inhibition potentials of the compounds have been primarily investigated by electrochemical techniques, such as linear polarization resistance, Tafel polarization curves, and electrochemical impedance spectroscopy.

ATP-Decorated Mesoporous Silica for Biomineralization of Calcium Carbonate and P2 Purinergic Receptor-Mediated Antitumor Activity against Aggressive Lymphoma.

Adenosine triphosphate (ATP) is an important transmitter that mediates various biological effects via purinergic receptors (P2 receptors) in cancer. We investigated the antitumor activity of ATP-decorated and doxorubicin (DOX)-loaded mesoporous silica with biomineralization of calcium carbonate against a highly aggressive and metastatic murine lymphoma called Dalton's lymphoma (DL). Our results suggest that this nanocomposite has unique effects with respect to the morphology and properties of calcium carbonate on the surface of the nanoparticle.

Protease-Responsive Targeted Delivery of Doxorubicin from Bilirubin-BSA-Capped Mesoporous Silica Nanoparticles against Colon Cancer.

Bilirubin is regarded as a toxic waste, produced from heme degradation and also acts as a potentially important antioxidant. Bilirubin causes arrest in cell cycle and lead to lesser occurrence of malignancies in individuals, having normal or slender increase in levels of serum bilirubin. Prompted by the dynamic interaction between bilirubin and bovine serum albumin (BSA), bilirubin-BSA complex was explored as a biocompatible cap system for protease responsive delivery device of anticancer drug against colon cancer.

Aggregation-induced enhanced green light emission from a simple donor-π-acceptor (D-π-A) material: a structure-property relationship study.

Organic D-π-A materials, possessing intramolecular charge transfer, have attracted much scientific attention in recent years because of their potential applications in the development of organic light emitting devices (OLEDs). Two new compounds, A1 and A2, having a D-π-A skeleton have been synthesized and single crystals were grown by the solution growth technique. Both compounds were characterized for crystallographic, thermal and photophysical properties.

Luminescence properties of Eu3+ doped CaMoO4 nanoparticles.

When Eu(3+) ions occupy Ca(2+) sites of CaMoO(4), which has a body centered tetragonal structure with inversion symmetry, only the magnetic dipole transition ((5)D(0)→(7)F(1)) should be allowed according to Judd-Ofelt theory. Even if there are a few distortions in the Eu(3+) environment, its intensity should be more than that of the electric dipole transition ((5)D(0)→(7)F(2)). We report here the opposite effect experimentally and ascribe this to the polarizability effect of the MoO(4) tetrahedron, which is neighboring to EuO(8) (symmetric environment).

Insilico studies of organosulfur-functional active compounds in garlic.

Garlic has been used medicinally since antiquity because of its antimicrobial activity, anticancer activity, antioxidant activity, ability to reduce cardiovascular diseases, improving immune functions, and antidiabetic activities and also in reducing cardiovascular diseases and improving immune functions. Recent studies identify that the wide variety of medicinal functions are attributed to the sulfur compounds present in garlic. Epidemiological observations and laboratory studies in animal models have also showed anticarcinogenic potential of organosulfur compounds of garlic.