F-FMISO-PET Hypoxia Monitoring for Head-and-Neck Cancer Patients: Radiomics Analyses Predict the Outcome of Chemo-Radiotherapy.

Tumor hypoxia is associated with radiation resistance and can be longitudinally monitored by F-fluoromisonidazole (F-FMISO)-PET/CT. Our study aimed at evaluating radiomics dynamics of F-FMISO-hypoxia imaging during chemo-radiotherapy (CRT) as predictors for treatment outcome in head-and-neck squamous cell carcinoma (HNSCC) patients. We prospectively recruited 35 HNSCC patients undergoing definitive CRT and longitudinal F-FMISO-PET/CT scans at weeks 0, 2 and 5 (W0/W2/W5).