Acquired von Willebrand disease in twins with autoimmune hypothyroidism: response to desmopressin and L-thyroxine therapy.

Because of menorrhagia, a 13-year-old girl was found to have type I von Willebrand disease and then chronic autoimmune thyroiditis with hypothyroidism. All clinical and laboratory evidence of von Willebrand disease resolved transiently after infusion of desmopressin, and permanently with L-thyroxine therapy. We recommend investigation for hypothyroidism in patients with newly diagnosed acquired von Willebrand disease.

Utah Growth Study: growth standards and the prevalence of growth hormone deficiency.

Serial measurements of elementary-school children were conducted for 2 consecutive years to assess height and growth velocity and to determine the prevalence of growth hormone deficiency (GHD) in American children. Trained volunteers measured 114,881 children the first year; 79,495 growth rates were calculated after the second measurements. The height and growth velocity curves generated were very similar to the currently used charts.

A cohort study of thyroid disease in relation to fallout from nuclear weapons testing.

Objective: To estimate individual radiation doses and current thyroid disease status for a previously identified cohort of 4818 schoolchildren potentially exposed to fallout from detonations of nuclear devices at the Nevada Test Site between 1951 and 1958.

Design: Cohort analytic study.

Setting: Communities in southwestern Utah, southeastern Nevada, and southeastern Arizona.

Natural history of thyroid abnormalities: prevalence, incidence, and regression of thyroid diseases in adolescents and young adults.

Purpose: This study reports the prevalence, incidence, and regression of thyroid abnormalities in a population observed from adolescence to adulthood.

Patients And Methods: Examinations for thyroid abnormalities were performed in 4,819 school-age children, ages 11 to 18, in 1965 to 1968; two thirds of this original cohort (3,121) were re-examined 20 years later (1985 to 1986). Each subject with a thyroid abnormality detected by physical examination was studied by means of a series of re-examinations, and tests of thyroid function, imaging, and biopsy to determine the exact nature of the thyroid abnormality.

Cohort study of thyroid disease near the Nevada Test Site: a preliminary report.

The atmospheric testing of nuclear weapons in Nevada beginning in 1951 resulted in exposure of regions surrounding the Nevada Test Site (NTS) to fallout. A cohort of children born between 1947 and 1954 in two counties near the NTS, one in Utah and one in Nevada (UT/NV), were examined in 1965-1968 for thyroid abnormalities that might have been a result of exposure to radioiodine in fallout. The prevalence of thyroid abnormalities in these children (11-18 y) was compared to that in a control group selected from a county in Arizona (AZ) that was presumed to have received little or no fallout from the NTS.

Development of a method to estimate thyroid dose from fallout radioiodine in a cohort study.

A cohort of 4831 persons aged 11-18 y in 1965 was identified among students in the schools of Washington County, UT; Lincoln County, NV; and Graham County, AZ. These children who had potentially been exposed to radioiodine from atomic weapons test fallout from the Nevada Test Site during 1951-1962 were selected for participation in a study of thyroid disease. The entire cohort was first examined during 1965-1968 for thyroid abnormalities.

High-carbohydrate, high-fiber diet in children with type I diabetes mellitus.

The effects of a high-carbohydrate, high-fiber (HCHF) diet on glucose control was evaluated in 12 children with type I diabetes mellitus. The children had had diabetes for an average of 5.25 yr; their mean glycosylated hemoglobin was 12.

Familial hyperphosphatasemia: diagnosis in early infancy and response to human thyrocalcitonin therapy.

Familial hyperphosphatasemia is an uncommon hereditary disorder of membranous bone with concurrent overproduction and overdestruction of bone and bone collagen by osteocytes. This process does not allow normal maturation into compact lamellar bone. Two cases of severely affected children are presented which demonstrate that the condition can be diagnosed in early infancy by abnormalities in the long bones.

Thyroid nodularity in children.

Of 5,179 school children surveyed in Utah, Nevada, and Arizona for thyroid abnormalities because of possible exposure to radiation from fallout, nodularity of the thyroid was found in 98 (1.8%). In 34, the nodularity represented lobulation associated with adolescent goiter, and in 31, thyroiditis.

Occurrence and natural history of chronic lymphocytic thyroiditis in childhood.

In a six-year survey of 5,179 school children in Arizona, Utah, and Nevada 62 cases of chronic lymphocytic thyroiditis were identified giving a prevalence of 1.2%. Thyroids were enlarged in 85%, firm in 60%, and had an irregular or lobulated surface in 75%.