Maintenance cognitive-behavioral therapy and manualized psychoeducation in the treatment of recurrent depression: a multicenter prospective randomized controlled trial.

Objective: This multicenter study compared the relapse and recurrence outcomes of two active treatments, maintenance cognitive-behavioral therapy (CBT) and manualized psychoeducation, both in addition to treatment as usual, in patients in remission from depression.

Method: This was a multicenter prospective randomized observer-blinded study with two parallel groups. The authors assessed 180 patients with three or more previous major depressive episodes who met remission criteria over a 2-month baseline period and who were randomly assigned to 16 sessions of either maintenance CBT or manualized psychoeducation over 8 months and then followed up for 12 months.

Cerebral correlates of selective attention in schizophrenic patients with formal thought disorder: a controlled H2 15O-PET study.

There is a widespread belief that formal thought disorders may be associated with disturbed selective attention in schizophrenia. Two hypotheses are derived: (1) patients with slightly pronounced formal thought disorders should differ from those with severely expressed formal thought disorders in terms of selective attention; and (2) the cerebral correlates of selective attention should be organised differently in mildly versus severely thought-disordered patients. We compared 20 female schizophrenic patients, one-half with mild, one-half with obvious formal thought disorders, and 10 control subjects on a neuropsychological battery and a cognitive activation task for selective attention (Go/NoGo) for the assessment of rCBF using H2 15O-PET.