Publications by authors named "Raktim Borkotoky"
We aimed to evaluate the significance of the RANTES-CCR5 axis and resulting immunomodulatory status in Dengue pathogenesis involving a Guwahati, India based population where Dengue cases have increased alarmingly. An increased CC-chemokine receptor type 5 (CCR5) messenger RNA expression and CCR5 positive cell count profile was observed in Dengue cases, the highest being in severe cases. CCR5 ligand RANTES expression was significantly decreased in Dengue cases and inversely correlated with Dengue viremia fold change in severe cases.
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- Gallbladder cancer (GBC) is a life-threatening disease with poor outcomes, and the study focuses on the role of oxidative stress and the base excision repair (BER) pathway in its development, especially in the North-East Indian population, where cases are rising.
- The research found that oxidative stress levels, indicated by 8-OH-dG, were significantly elevated in patients with gallbladder issues like cholelithiasis and cholecystitis, correlating with the severity of GBC.
- Key BER pathway genes were downregulated in GBC patients, and specific genetic polymorphisms were associated with both disease susceptibility and severity, suggesting that targeting oxidative stress markers and BER genes might offer new therapeutic strategies
XRCC1 gene is an integral component of the base excision repair pathway regulating DNA repair, the genetic alterations in which has been documented to be associated with cancers of multiple etiologies. The present study aimed to evaluate the key polymorphisms in XRCC1 gene for its association with pathogenesis of oral cavity cancer (OCC) in Kamrup Urban District of Assam, India. Tissue biopsies (N = 152) clinicopathologically characterized OCCs were collected along with whole blood samples (N = 190) from healthy controls with all clinical and habitual details.
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