Nanoformulated fisetin ameliorates Alzheimer's disease via reducing proinflammatory cytokines and activating the NRF2/HO-1 pathway.

The study aimed to evaluate the neuroprotective effect of a chitosan-coated fisetin nanoformulation in an experimental Alzheimer's disease (AD) model, focusing on improving fisetin's pharmacokinetics and exploring its impact on both brain and colon pathology. AD was induced in mice by intracerebroventricular administration of Aβ. Mice were treated with either fisetin or a fisetin nanoformulation (5 mg/kg/day, orally) for 21 days.

Formulation and Characterization of Silibinin Entrapped Nano-Liquid Crystals for Activity against Aβ Neurotoxicity in In-Vivo Model.

Silibinin (SIL) Encapsulated Nanoliquid Crystalline (SIL-NLCs) particles were prepared to study neuroprotective effect against amyloid beta (Aβ) neurotoxicity in Balb/c mice model. Theses NLCs were prepared through hot emulsification and probe sonication technique. The pharmacodynamics was investigatigated on Aβ intracerebroventricular (ICV) injected Balb/c mice.

Long-term impacts of the Bandebereho programme on violence against women and children, maternal health-seeking, and couple relations in Rwanda: a six-year follow-up of a randomised controlled trial.

Background: Programmes that work with parents to build couple relationship and parenting skills and include critical reflection on gender norms are a promising approach for reducing violence against women and children. However, there is limited evidence of their longer-term impact. In Rwanda, the Bandebereho programme engaged expectant and current parents of children under five years.

Vitamin E modified polyamidoamine dendrimer for piperine delivery to alleviate Aβ induced neurotoxicity in Balb/c mice model.

In Alzheimer's disease (AD), amyloid beta (Aβ) aggregate formation and neurofibrillary tangles are major pathological hallmarks which are related to neurodegeneration in the brain. To alleviate Aβ fibrils toxicity vitamin E derivative tocopheryl polyethylene glycol succinate (TPGS) was conjugated with polyamidoamine (PAMAM) dendrimer through carbodiimide reaction to synthesize TPGS-PAMAM. This TPGS-PAMAM was employed to entrap neuroprotective agent piperine (PIP) through an anti-solvent technique to prepare PIP-TPGS-PAMAM.

Fisetin attenuates arsenic and fluoride subacute co-exposure induced neurotoxicity via regulating TNF-α mediated activation of NLRP3 inflammasome.

Groundwater is considered safe, however, the occurrence of contaminants like arsenic and fluoride has raised a major healthcare concern. Clinical studies suggested that arsenic and fluoride co-exposure induced neurotoxicity, however efforts to explore safe and effective management of such neurotoxicity are limited. Therefore, we investigated the ameliorative effect of Fisetin against arsenic and fluoride subacute co-exposure-induced neurotoxicity, and associated biochemical and molecular changes.

The microbiome-gut-brain axis in epilepsy: pharmacotherapeutic target from bench evidence for potential bedside applications.

The gut-brain axis augments the bidirectional communication between the gut and brain and modulates gut homeostasis and the central nervous system through the hypothalamic-pituitary-adrenal axis, enteroendocrine system, neuroendocrine system, inflammatory and immune pathways. Preclinical and clinical reports showed that gut dysbiosis might play a major regulatory role in neurological diseases such as epilepsy, Parkinson's, multiple sclerosis, and Alzheimer's disease. Epilepsy is a chronic neurological disease that causes recurrent and unprovoked seizures, and numerous risk factors are implicated in developing epilepsy.

The Pharmacological Activity of Garlic () in Parkinson's Disease: From Molecular Mechanisms to the Therapeutic Potential.

Parkinson's disease (PD), one of the most common neurological diseases worldwide, is mainly characterized neuropathologically by the dopaminergic neurodegeneration in the substantia nigra pars compacta of the brainstem. Genetic and environmental factors contribute to PD pathophysiology through modulation of pleiotropic cellular mechanisms. The currently available treatment options focus only on replenishing dopamine and do not alter disease progression.

Numerical modeling and development of a dual lung simulator using partitioned fluid-structure interaction approach for ventilator testing.

New designs of mechanical ventilators require extensive testing before utilizing the ventilator on a patient. Test lungs are commonly used to understand the behavior of new designs of ventilators and the lung mechanics. The current study aims to develop a numerical model of dual test lungs utilizing the partitioned fluid-structure interaction (FSI) approach and test it against the available experimental data of volume-controlled ventilation.

Ventilation Performance Evaluation of a Negative-Pressurized Isolation Room for Emergency Departments.

Due to the emergence of COVID-19 becoming a significant pandemic worldwide, hospitals are expected to be capable and flexible in responding to the pandemic situation. Moreover, as frontline healthcare staff, emergency department (ED) staff have a high possibility of exposure risk to infectious airborne. The ED isolation room will possibly and effectively isolate the infected patient, therefore safekeeping frontline healthcare staff and controlling the outbreak.

Genetic and mutational analysis of virulence traits and their modulation in an environmental toxigenic non-O1/non-O139 strain, VCE232.

O1 and O139 isolates deploy cholera toxin (CT) and toxin-coregulated pilus (TCP) to cause the diarrhoeal disease cholera. The and genes encoding CT and TCP are part of two acquired genetic elements, the CTX phage and pathogenicity island-1 (VPI-1), respectively. ToxR and ToxT proteins are the key regulators of virulence genes of O1 and O139.

Infection Control Improvement of a Negative-Pressurized Pediatric Intensive Care Unit.

The COVID-19 pandemic caused by the novel SARS-CoV-2 virus raises alarming concern around the healthcare facilities due to the significant increase in patient inflow. Negative-pressurized isolation rooms have been utilized in various health care facilities to isolate the patients from active community contact. Several studies have highlighted isolation rooms improvement.

Performance Improvement of a Negative-Pressurized Isolation Room for Infection Control.

Negative-pressurized isolation rooms have been approved effectively and applied widely for infectious patients. However, the outbreak of COVID-19 has led to a huge demand for negative-pressurized isolation rooms. It is critical and essential to ensure infection control performance through best practice of ventilation systems and optimum airflow distribution within isolation rooms.

Functional Insights Into the Role of in (p)ppGpp Metabolism of .

The stringent response, an adaptive response to nutrient limitation and exposure to xenobiotics in bacteria, is mediated by two intracellular signaling molecules, pppGpp and ppGpp, together called (p)ppGpp. The cellular level of (p)ppGpp in bacterial cells is controlled by the Rel/Spo family of proteins. In the cholera pathogen, , (p)ppGpp metabolism is regulated by the products of at least three genes , , and .

Simulating Twistronics without a Twist.

Rotational misalignment or twisting of two monolayers of graphene strongly influences its electronic properties. Structurally, twisting leads to large periodic supercell structures, which in turn can support intriguing strongly correlated behavior. Here, we propose a highly tunable scheme to synthetically emulate twisted bilayer systems with ultracold atoms trapped in an optical lattice.

Elemental composition of aquaculture fish from West Bengal, India: nutrition versus food safety.

Aquaculture production continues to grow in West Bengal, where on average people consume 8.2 kg capita of fish each year, and an extensive mosaic of aquaculture ponds has developed along the River Hugli as clay pits are repurposed. The adjacent brickworks and industry (especially tanneries) are a source of environmental pollution, with potential for bioaccumulation of potentially harmful elements (PHEs) in fish farmed in these ponds.

On the observability of Pauli crystals in experiments with ultracold trapped Fermi gases.

The best known manifestation of the Fermi-Dirac statistics is the Pauli exclusion principle: no two identical fermions can occupy the same one-particle state. This principle enforces high-order correlations in systems of many identical fermions and is responsible for a particular geometric arrangement of trapped particles even when all mutual interactions are absent. These geometric structures, called Pauli crystals, are predicted for a system of N identical atoms trapped in a harmonic potential.

Bioindicator role of tintinnid (Protozoa: Ciliophora) for water quality monitoring in Kalpakkam, Tamil Nadu, south east coast of India.

The feasibility of a potential bioindicator based on functional groups of microzooplankton tintinnids for bioassessments of water quality status was studied during southwest monsoon (June to September) along the coastal waters of Kalpakkam, India during 2012-2015. The work highlights the following features (1) tintinnid community composed of 28 species belonging to 11 genera and 9 families, revealed significant differences among the four study sites (2) maximum numerical abundance (2224±90ind. l) and species diversity (H'=2.

Quantum discord length is enhanced while entanglement length is not by introducing disorder in a spin chain.

Classical correlation functions of ground states typically decay exponentially and polynomially, respectively, for gapped and gapless short-range quantum spin systems. In such systems, entanglement decays exponentially even at the quantum critical points. However, quantum discord, an information-theoretic quantum correlation measure, survives long lattice distances.

Bioaccumulation of trace elements in dominant mesozooplankton group inhabiting in the coastal regions of Indian Sundarban mangrove wetland.

Mesozooplankton (Body size 20-200 μm) along with the surface water were collected from coastal regions of Sundarban, northeastern part of Bay of Bengal considering three seasons, namely premonsoon, monsoon and postmonsoon. Samples were analyzed for community structure and the dominant copepod species were further analyzed for trace metal concentration. In total, 50 copepods were identified (22 families and 43 genera).

Impact of multispecies diatom bloom on plankton community structure in Sundarban mangrove wetland, India.

A multispecies bloom caused by the centric diatoms, viz. Coscinodiscus radiatus, Chaetoceros lorenzianus and the pennate diatom Thalassiothrix frauenfeldii was investigated in the context of its impact on phytoplankton and microzooplankton (the loricate ciliate tintinnids) in the coastal regions of Sagar Island, the western part of Sundarban mangrove wetland, India. Both number (15-18 species) and cell densities (12.

Seasonal variations in species composition, abundance, biomass and production rate of tintinnids (Ciliata: Protozoa) along the Hooghly (Ganges) River Estuary, India: a multivariate approach.

The study is the first documentation of seasonal variations in species composition, abundance and diversity of tintinnid (Ciliata: Protozoa), in relation to water quality parameters along the stretch of the Hooghly (Ganges) River Estuary (HRE), eastern coastal part of India. A total of 26 species (22 agglomerated and 4 non-agglomerated) belonging to 8 genera has been identified from 8 study sites where Tintinnopsis (17 species) represented the most dominant genera, contributing up to 65 % of total tintinnid community followed by Tintinnidium (2 species), Leprotintinnus (2 species) and Dadayiella, Favella, Metacylis, Eutintinnus and Helicostomella (each with solitary species). The maximum (1,666 ind.

Levels and chemical speciation of arsenic in representative biota and sediments of a tropical mangrove wetland, India.

The general concern for arsenic in the marine environment is associated with its wide distribution and potential toxicity. In the present work, concentrations and chemical speciation of arsenic were characterized in sediments and representative biota from the Indian Sundarban, the largest continuous mangrove tract formed at the mouth of the Hugli (Ganges) River estuary, northeastern part of the Bay of Bengal. Analyzed organisms included both shellfish (Macoma birmanica, Sanguinolaria acuminata and Meretrix meretrix) and finfish (Liza parsia, Liza tade, Harpodon nehereus and Eleutheronema tetradactylum).

Perfluorinated compounds in surficial sediments of the Ganges River and adjacent Sundarban mangrove wetland, India.

This study reports the first evidence of the quantification of two dominant perfluorinated compounds (PFCs), namely perfluorooctanesulfate (PFOS) and perfluorooctannoate (PFOA), in surface sediment samples (0-5 cm; n=13) from the Ganges (Hugli) River including Sundarban wetland, India using HPLC-MS/MS. The concentrations of PFOA exhibited a wide range of concentrations from <0.5 to 14.